{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T01:48:33Z","timestamp":1778809713752,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,11,8]],"date-time":"2016-11-08T00:00:00Z","timestamp":1478563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2017,4]]},"abstract":"\n Objective<\/jats:title>\n \n To identify factors associated with regional recurrence after lymph node dissection (\n LND<\/jats:styled-content>\n ) for squamous cell carcinoma (\n SCC<\/jats:styled-content>\n ) to determine which patients might benefit from adjuvant therapy.\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n Men who underwent\n LND<\/jats:styled-content>\n for penile\n SCC<\/jats:styled-content>\n from 1977 to 2014 were identified from an institutional database. Kaplan\u2013Meier curves estimated recurrence\u2010free survival (\n RFS<\/jats:styled-content>\n ) calculated from the date of\n LND<\/jats:styled-content>\n . Cox regression models evaluated the association between\n RFS<\/jats:styled-content>\n and patient and tumour characteristics.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In all, 182 men who underwent\n LND<\/jats:styled-content>\n for penile\n SCC<\/jats:styled-content>\n were identified. The median patient age was 62 years and the median follow\u2010up was 4.2 years. After\n LND<\/jats:styled-content>\n 34 men had regional recurrence, of which 24 developed isolated regional recurrences without distant metastasis. The median\n RFS<\/jats:styled-content>\n was 5.7 months, and the 3\u2010year\n RFS<\/jats:styled-content>\n rate was 70%. On univariate analysis, lymphovascular invasion, clinical and pathological nodal stage, pathological inguinal laterality, pelvic nodal involvement, lymph node density \u22655.2%, \u22653 pathologically involved lymph nodes, and extranodal extension (\n ENE<\/jats:styled-content>\n ) were associated with worse\n RFS<\/jats:styled-content>\n (all\n P<\/jats:italic>\n < 0.05). On multivariate analysis, clinical N3 disease [adjusted hazard ratio (\n AHR<\/jats:styled-content>\n )] 3.53, 95% confidence interval (\n CI<\/jats:styled-content>\n ) 1.68\u20137.45;\n P<\/jats:italic>\n = 0.001), \u22653 pathologically involved lymph nodes (\n AHR<\/jats:styled-content>\n 3.78, 95%\n CI<\/jats:styled-content>\n 2.12\u20136.65;\n P<\/jats:italic>\n < 0.001), and\n ENE<\/jats:styled-content>\n (\n AHR<\/jats:styled-content>\n 3.32, 95%\n CI<\/jats:styled-content>\n 1.93\u20135.76;\n P<\/jats:italic>\n < 0.001) were associated with worse\n RFS<\/jats:styled-content>\n . The 3\u2010year\n RFS<\/jats:styled-content>\n for patients with\n cN<\/jats:styled-content>\n 0,\n cN<\/jats:styled-content>\n 1,\n cN<\/jats:styled-content>\n 2, and\n cN<\/jats:styled-content>\n 3 disease was 91.7%, 64.5%, 54.7%, and 38.3%, respectively. For men with \u22653 involved nodes, the 3\u2010year\n RFS<\/jats:styled-content>\n was 17% vs 82.4% in men with <3 involved nodes. The 3\u2010year\n RFS<\/jats:styled-content>\n was 29.7% in men with\n ENE<\/jats:styled-content>\n and 85.7% in men without ENE.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The presence of clinical N3 disease, \u22653 pathologically involved lymph nodes, and\n ENE<\/jats:styled-content>\n was associated with worse\n RFS<\/jats:styled-content>\n . As regional recurrence portends a dismal prognosis with few salvage options, adjuvant therapies should be developed for men with the aforementioned adverse factors.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.13686","type":"journal-article","created":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T04:16:42Z","timestamp":1476764202000},"page":"591-597","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Factors associated with regional recurrence after lymph node dissection for penile squamous cell carcinoma"],"prefix":"10.1111","volume":"119","author":[{"given":"Jay P.","family":"Reddy","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Curtis A.","family":"Pettaway","sequence":"additional","affiliation":[{"name":"Department of Urology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence B.","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lance C.","family":"Pagliaro","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pheroze","family":"Tamboli","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priya","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isuru","family":"Jayaratna","sequence":"additional","affiliation":[{"name":"Department of Urology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen E.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.2001.00379.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.10.059"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20414"},{"key":"e_1_2_7_5_1","unstructured":"National Comprehensive Cancer Network (NCCN).Penile Cancer 2015. 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