{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:52:13Z","timestamp":1792180333955,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T00:00:00Z","timestamp":1481241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To describe the management strategies and outcomes of patients with renal medullary carcinoma (\n                      <jats:styled-content style=\"fixed-case\">RMC<\/jats:styled-content>\n                      ) and characterise predictors of overall survival (\n                      <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">RMC<\/jats:styled-content>\n                      is a rare and aggressive malignancy that afflicts young patients with sickle cell trait; there are limited data on management to date. This is a study of patients with\n                      <jats:styled-content style=\"fixed-case\">RMC<\/jats:styled-content>\n                      who were treated in 2000\u20132015 at eight academic institutions in North America and France. The Kaplan\u2013Meier method was used to estimate\n                      <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>\n                      , measured from initial\n                      <jats:styled-content style=\"fixed-case\">RMC<\/jats:styled-content>\n                      diagnosis to date of death. Cox regression analysis was used to determine predictors of\n                      <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In all, 52 patients (37 males) were identified. The median (range) age at diagnosis was 28 (9\u201348) years and 49 patients (94%) had stage\n                      <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\n                      \/\n                      <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\n                      . The median\n                      <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>\n                      for all patients was 13.0 months and 38 patients (75%) had nephrectomy. Patients who underwent nephrectomy had superior\n                      <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>\n                      compared to patients who were treated with systemic therapy only (median\n                      <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>\n                      16.4 vs 7.0 months,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001). In all, 45 patients received chemotherapy and 13 (29%) had an objective response; 28 patients received targeted therapies, with 8\u2010week median therapy duration and no objective responses. Only seven patients (13%) survived for &gt;24 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">RMC<\/jats:styled-content>\n                      carries a poor prognosis. Chemotherapy provides palliation and remains the mainstay of therapy, but &lt;20% of patients survive for &gt;24 months, underscoring the need to develop more effective therapy for this rare tumour. In this study, nephrectomy was associated with improved\n                      <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.13705","type":"journal-article","created":{"date-parts":[[2016,11,8]],"date-time":"2016-11-08T08:37:41Z","timestamp":1478594261000},"page":"782-792","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["Management and outcomes of patients with renal medullary carcinoma: a multicentre collaborative study"],"prefix":"10.1111","volume":"120","author":[{"given":"Amishi Y.","family":"Shah","sequence":"first","affiliation":[{"name":"MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose A.","family":"Karam","sequence":"additional","affiliation":[{"name":"MD Anderson Cancer Center Houston TX 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