{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:16:02Z","timestamp":1762899362164,"version":"build-2065373602"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,12,5]],"date-time":"2016-12-05T00:00:00Z","timestamp":1480896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2017,9]]},"abstract":"\n Objectives<\/jats:title>\n \n To evaluate, in a prospective study, the effectiveness of computed tomography (\n CT<\/jats:styled-content>\n )\u2010matched 11C\u2010acetate (\n AC<\/jats:styled-content>\n ) positron\u2010emission tomography (\n PET<\/jats:styled-content>\n ) in patients with prostate cancer (\n PC<\/jats:styled-content>\n a) who had prostate\u2010specific antigen (\n PSA<\/jats:styled-content>\n ) relapse after radical prostatectomy (\n RP<\/jats:styled-content>\n ) or radiotherapy (\n RT<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n In 103 relapsing patients after\n RP<\/jats:styled-content>\n (\n n<\/jats:italic>\n = 97) or\n RT<\/jats:styled-content>\n (\n n<\/jats:italic>\n = 6)\n AC<\/jats:styled-content>\n \u2010\n PET<\/jats:styled-content>\n images and\n CT<\/jats:styled-content>\n scans were obtained. In patients with\n AC<\/jats:styled-content>\n \u2010\n PET<\/jats:styled-content>\n \u2010positive results with localized\n PC<\/jats:styled-content>\n a recurrence, detected lesions were resected and histologically verified or, after local\n RT<\/jats:styled-content>\n , followed\u2010up by\n PSA<\/jats:styled-content>\n testing. Patients with distant disease on\n AC<\/jats:styled-content>\n \u2010\n PET<\/jats:styled-content>\n were treated with androgen deprivation\/chemotherapy.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 103 patients, 42 were\n AC<\/jats:styled-content>\n \u2010\n PET<\/jats:styled-content>\n \u2010positive.\n PSA<\/jats:styled-content>\n levels were <1.0, <2.0 and <4.0 ng\/mL in six, 16 and 20 patients, respectively. In 25\/42 patients\n AC<\/jats:styled-content>\n \u2010\n PET<\/jats:styled-content>\n suggested lymph node metastases: 16\/25 patients underwent surgery (10\/16 metastasis, 6\/16 inflammation); 9\/25 patients underwent\n RT<\/jats:styled-content>\n of lymph node metastases, which was followed by decreasing\n PSA<\/jats:styled-content>\n level. In 17\/42 patients who had distant disease, systemic treatment was commenced. Combining patients who underwent surgery and those who underwent\n RT<\/jats:styled-content>\n , 19\/25 patients were true\u2010positive in terms of\n AC<\/jats:styled-content>\n \u2010\n PET<\/jats:styled-content>\n (positive predictive value 76%). In 5\/19 patients,\n PSA<\/jats:styled-content>\n level was <2.0 ng\/mL, in 2\/19 patients it was <1.0 ng\/mL and in 14\/19 patients it was 5.4\u201323.1 ng\/mL. In\n AC<\/jats:styled-content>\n \u2010\n PET<\/jats:styled-content>\n \u2010positive patients after surgery or\n RT<\/jats:styled-content>\n (without androgen deprivation), median (range) time to renewed\n PSA<\/jats:styled-content>\n increase was 6 (5\u20139) months.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Only a minority of patients with relapsing\n PC<\/jats:styled-content>\n a appear to benefit from\n AC<\/jats:styled-content>\n \u2010\n PET<\/jats:styled-content>\n for guiding potential local treatment. False\u2010positive results show that factors other than tumour metabolism induce increased\n AC<\/jats:styled-content>\n uptake. The time free of recurrence after local treatment was shorter than expected.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.13706","type":"journal-article","created":{"date-parts":[[2016,11,8]],"date-time":"2016-11-08T21:23:10Z","timestamp":1478640190000},"page":"337-342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["11C\u2010acetate positron\u2010emission tomography\/computed tomography imaging for detection of recurrent disease after radical prostatectomy or radiotherapy in patients with prostate cancer"],"prefix":"10.1111","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1473-004X","authenticated-orcid":false,"given":"Lukas Hendrik","family":"Esch","sequence":"first","affiliation":[{"name":"Department of Urology St Antonius Hospital Gronau 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