{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:33:40Z","timestamp":1791232420013,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T00:00:00Z","timestamp":1489104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2017,6]]},"abstract":"\n Objective<\/jats:title>\n \n To report the oncological outcome of salvage high\u2010intensity focused ultrasound (S\u2010\n HIFU<\/jats:styled-content>\n ) for locally recurrent prostate cancer after external beam radiotherapy (\n EBRT<\/jats:styled-content>\n ) from a multicentre database.\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n This retrospective study comprises patients from nine centres with local recurrent disease after\n EBRT<\/jats:styled-content>\n treated with S\u2010\n HIFU<\/jats:styled-content>\n from 1995 to 2009. The biochemical failure\u2010free survival (\n bFFS<\/jats:styled-content>\n ) rate was based on the \u2018Phoenix\u2019 definition (\n PSA<\/jats:styled-content>\n nadir + 2 ng\/mL). Secondary endpoints included progression to metastasis and cancer\u2010specific death. Kaplan\u2013Meier analysis was performed examining overall (\n OS<\/jats:styled-content>\n ), cancer\u2010specific (\n CSS<\/jats:styled-content>\n ) and metastasis\u2010free survival (\n MFS<\/jats:styled-content>\n ). Adverse events and quality of life status are reported.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In all, 418 patients with a mean (\n SD<\/jats:styled-content>\n ) follow\u2010up of 3.5 (2.5) years were included. The mean (\n SD<\/jats:styled-content>\n ) age was 68.6 (5.8) years and the\n PSA<\/jats:styled-content>\n level before S\u2010\n HIFU<\/jats:styled-content>\n was 6.8 (7.8) ng\/\n mL<\/jats:styled-content>\n . The median\n PSA<\/jats:styled-content>\n nadir after S\u2010\n HIFU<\/jats:styled-content>\n was 0.19 ng\/\n mL<\/jats:styled-content>\n . The\n OS<\/jats:styled-content>\n ,\n CSS<\/jats:styled-content>\n and\n MFS<\/jats:styled-content>\n rates at 7 years were 72%, 82% and 81%, respectively. At 5 years the\n bFFS<\/jats:styled-content>\n rate was 58%, 51% and 36% for pre\u2010\n EBRT<\/jats:styled-content>\n low\u2010, intermediate\u2010 and high\u2010risk patients, respectively. The 5\u2010year\n bFFS<\/jats:styled-content>\n rate was 67%, 42% and 22% for pre\u2010S\u2010\n HIFU PSA<\/jats:styled-content>\n level \u22644, 4\u201310 and \u226510 ng\/\n mL<\/jats:styled-content>\n , respectively. Complication rates decreased after the introduction of specific post\u2010\n RT<\/jats:styled-content>\n parameters: incontinence (grade\n II<\/jats:styled-content>\n or\n III<\/jats:styled-content>\n ) from 32% to 19% (\n P<\/jats:italic>\n = 0.002); bladder outlet obstruction or stenosis from 30% to 15% (\n P<\/jats:italic>\n = 0.003); recto\u2010urethral fistula decreased from 9% to 0.6% (\n P<\/jats:italic>\n < 0.001). Study limitations include being a retrospective analysis from a registry with no control group.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n S\u2010\n HIFU<\/jats:styled-content>\n for locally recurrent prostate cancer after failed\n EBRT<\/jats:styled-content>\n is associated with 7\u2010year\n CSS<\/jats:styled-content>\n and\n MFS<\/jats:styled-content>\n rates of >80% at a price of significant morbidity. S\u2010\n HIFU<\/jats:styled-content>\n should be initiated early following\n EBRT<\/jats:styled-content>\n failure\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.13766","type":"journal-article","created":{"date-parts":[[2017,1,7]],"date-time":"2017-01-07T02:41:49Z","timestamp":1483756909000},"page":"896-904","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Salvage high\u2010intensity focused ultrasound (\n HIFU<\/scp>\n ) for locally recurrent prostate cancer after failed radiation therapy: Multi\u2010institutional analysis of 418 patients"],"prefix":"10.1111","volume":"119","author":[{"given":"Sebastien","family":"Crouzet","sequence":"first","affiliation":[{"name":"Department of Urology Edouard Herriot Hospital Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Blana","sequence":"additional","affiliation":[{"name":"Department of Urology Fuerth Hospital F\u00fcrth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois J.","family":"Murat","sequence":"additional","affiliation":[{"name":"Urology Department Val d'Ouest Hospital Ecully France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Pasticier","sequence":"additional","affiliation":[{"name":"Department of Urology CHU Pellegrin Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C. 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