{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T10:24:34Z","timestamp":1781173474447,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,2,19]],"date-time":"2017-02-19T00:00:00Z","timestamp":1487462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572536"],"award-info":[{"award-number":["81572536"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672850"],"award-info":[{"award-number":["81672850"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["14140901700"],"award-info":[{"award-number":["14140901700"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["16411969800"],"award-info":[{"award-number":["16411969800"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","award":["15ZZ058"],"award-info":[{"award-number":["15ZZ058"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2017,8]]},"abstract":"\n Objective<\/jats:title>\n \n To determine the prognostic utility of serum chromogranin A (CgA) and neurone\u2010specific enolase (\n NSE<\/jats:styled-content>\n ) variations during the first 3 months of abiraterone acetate (\n AA<\/jats:styled-content>\n ) treatment in patients with metastatic castration\u2010resistant prostate cancer (\n mCRPC<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n The serum levels of CgA,\n NSE<\/jats:styled-content>\n were measured at baseline and after 3 months of\n AA<\/jats:styled-content>\n treatment in 40 patients with\n mCRPC<\/jats:styled-content>\n . Outcome measures were prostate\u2010specific antigen progression\u2010free survival (\n PSA<\/jats:styled-content>\n \u2010\n PFS<\/jats:styled-content>\n ), radiographic\n PFS<\/jats:styled-content>\n (\n rPFS<\/jats:styled-content>\n ), and overall survival (\n OS<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n CgA levels were not correlated with\n NSE<\/jats:styled-content>\n levels (\n P<\/jats:italic>\n = 0.296). In multivariate analysis the combination of CgA and\n NSE<\/jats:styled-content>\n (\u22651 marker positive vs both markers negative) and the combination of CgA and\n NSE<\/jats:styled-content>\n elevation during the first 3 months of\n AA<\/jats:styled-content>\n treatment (\u22651 marker positive vs both markers negative) remained significant predictors of\n OS<\/jats:styled-content>\n ,\n rPFS<\/jats:styled-content>\n , and\n PSA<\/jats:styled-content>\n \u2010\n PFS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n We found that CgA and\n NSE<\/jats:styled-content>\n elevation during the first 3 months of\n AA<\/jats:styled-content>\n treatment and elevated baseline CgA and\n NSE<\/jats:styled-content>\n levels were independent prognostic factors for\n OS<\/jats:styled-content>\n ,\n rPFS<\/jats:styled-content>\n and\n PSA<\/jats:styled-content>\n \u2010\n PFS<\/jats:styled-content>\n in patients with\n mCRPC<\/jats:styled-content>\n treated with\n AA<\/jats:styled-content>\n . This suggests that serial CgA and\n NSE<\/jats:styled-content>\n evaluation may help clinicians in distinguishing patients with\n mCRPC<\/jats:styled-content>\n who would obtain the best survival benefit from\n AA<\/jats:styled-content>\n treatment.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.13781","type":"journal-article","created":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T16:54:25Z","timestamp":1484931265000},"page":"226-232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Chromogranin A and neurone\u2010specific enolase variations during the first 3 months of abiraterone therapy predict outcomes in patients with metastatic castration\u2010resistant prostate cancer"],"prefix":"10.1111","volume":"120","author":[{"given":"Liancheng","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Urology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 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