{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:08:35Z","timestamp":1781176115384,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T00:00:00Z","timestamp":1490918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To develop and externally validate a predictive model for detection of significant prostate cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      Development of the model was based on a prospective cohort including 393 men who underwent multiparametric magnetic resonance imaging (mp\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      ) before biopsy. External validity of the model was then examined retrospectively in 198 men from a separate institution whom underwent mp\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      followed by biopsy for abnormal prostate\u2010specific antigen (\n                      <jats:styled-content style=\"fixed-case\">PSA<\/jats:styled-content>\n                      ) level or digital rectal examination (\n                      <jats:styled-content style=\"fixed-case\">DRE<\/jats:styled-content>\n                      ). A model was developed with age,\n                      <jats:styled-content style=\"fixed-case\">PSA<\/jats:styled-content>\n                      level,\n                      <jats:styled-content style=\"fixed-case\">DRE<\/jats:styled-content>\n                      , prostate volume, previous biopsy, and Prostate Imaging Reporting and Data System (\n                      <jats:styled-content style=\"fixed-case\">PIRADS<\/jats:styled-content>\n                      ) score, as predictors for significant prostate cancer (Gleason 7 with &gt;5% grade 4, \u226520% cores positive or \u22657 mm of cancer in any core). Probability was studied via logistic regression. Discriminatory performance was quantified by concordance statistics and internally validated with bootstrap resampling.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In all, 393 men had complete data and 149 (37.9%) had significant prostate cancer. While the variable model had good accuracy in predicting significant prostate cancer, area under the curve (\n                      <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>\n                      ) of 0.80, the advanced model (incorporating mp\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      ) had a significantly higher\n                      <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>\n                      of 0.88 (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001). The model was well calibrated in internal and external validation. Decision analysis showed that use of the advanced model in practice would improve biopsy outcome predictions. Clinical application of the model would reduce 28% of biopsies, whilst missing 2.6% significant prostate cancer.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Individualised risk assessment of significant prostate cancer using a predictive model that incorporates mp\n                      <jats:styled-content style=\"fixed-case\">MRI PIRADS<\/jats:styled-content>\n                      score and clinical data allows a considerable reduction in unnecessary biopsies and reduction of the risk of over\u2010detection of insignificant prostate cancer at the cost of a very small increase in the number of significant cancers missed.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.13814","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T12:46:44Z","timestamp":1487249204000},"page":"774-781","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":118,"title":["A multiparametric magnetic resonance imaging\u2010based risk model to determine the risk of significant prostate cancer prior to biopsy"],"prefix":"10.1111","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5531-6104","authenticated-orcid":false,"given":"Pim J.","family":"van Leeuwen","sequence":"first","affiliation":[{"name":"St. Vincent's Prostate Cancer Centre Darlinghurst New South Wales Australia"},{"name":"Garvan Institute of Medical Research\/The Kinghorn Cancer Centre Darlinghurst New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Hayen","sequence":"additional","affiliation":[{"name":"School of Public Health and Community Medicine Kensington New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Thompson","sequence":"additional","affiliation":[{"name":"St. Vincent's Prostate Cancer Centre Darlinghurst New South Wales Australia"},{"name":"Garvan Institute of Medical Research\/The Kinghorn Cancer Centre Darlinghurst New South Wales Australia"},{"name":"School of Public Health and Community Medicine Kensington New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Moses","sequence":"additional","affiliation":[{"name":"School of Medicine University of New South Wales Kensington New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Shnier","sequence":"additional","affiliation":[{"name":"School of Medicine University of New South Wales Kensington New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maret","family":"B\u00f6hm","sequence":"additional","affiliation":[{"name":"Garvan Institute of Medical Research\/The Kinghorn Cancer Centre Darlinghurst New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdaline","family":"Abuodha","sequence":"additional","affiliation":[{"name":"Garvan Institute of Medical Research\/The Kinghorn Cancer Centre Darlinghurst New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Maree","family":"Haynes","sequence":"additional","affiliation":[{"name":"Garvan Institute of Medical Research\/The Kinghorn Cancer Centre Darlinghurst New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5805-9860","authenticated-orcid":false,"given":"Francis","family":"Ting","sequence":"additional","affiliation":[{"name":"St. Vincent's Prostate Cancer Centre Darlinghurst New South Wales Australia"},{"name":"Garvan Institute of Medical Research\/The Kinghorn Cancer Centre Darlinghurst New South Wales Australia"},{"name":"School of Public Health and Community Medicine Kensington New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelle","family":"Barentsz","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Radboud University Medical Centre Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Roobol","sequence":"additional","affiliation":[{"name":"Department of Urology Erasmus University Medical Center Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Vass","sequence":"additional","affiliation":[{"name":"Department of Urology Royal North Shore Private Hospital St Leonards New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishan","family":"Rasiah","sequence":"additional","affiliation":[{"name":"Department of Urology Royal North Shore Private Hospital St Leonards New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warick","family":"Delprado","sequence":"additional","affiliation":[{"name":"Douglass Hanly Moir Pathology and University of Notre Dame Darlinghurst New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip D.","family":"Stricker","sequence":"additional","affiliation":[{"name":"St. Vincent's Prostate Cancer Centre Darlinghurst New South Wales Australia"},{"name":"Garvan Institute of Medical Research\/The Kinghorn Cancer Centre Darlinghurst New South Wales Australia"},{"name":"School of Public Health and Community Medicine Kensington New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,31]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"American Cancer Society Inc.Global Cancer Facts & Figures 2015. Available at:https:\/\/old.cancer.org\/acs\/groups\/content\/@editorial\/documents\/document\/acspc-044552.pdf. Accessed February 2017."},{"key":"e_1_2_9_3_1","unstructured":"Australia Government Cancer Australia.Prostate cancer in Australia 2015. Available at:https:\/\/prostate-cancer.canceraustralia.gov.au\/statistics. Accessed February 2017"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25516"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/95.12.868"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2009.08.025"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60525-0"},{"key":"e_1_2_9_8_1","first-page":"CD004720","article-title":"Screening for prostate cancer","volume":"1","author":"Ilic D","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1201637"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.10.140"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.01.013"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.11.029"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.03.030"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-011-2377-y"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2014.01.014"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2307\/2986270"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-0698"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2009.12.004"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1311593"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.20840"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj131"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2010.09727.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.22470"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2009.03.029"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.06.025"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.04.028"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv095"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12381"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24317"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.10.033"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.12.012"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.02.072"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.01.035"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbju.13814","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.13814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:15:54Z","timestamp":1761743754000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.13814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,31]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/bju.13814"],"URL":"https:\/\/doi.org\/10.1111\/bju.13814","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,31]]},"assertion":[{"value":"2017-03-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}