{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T17:10:04Z","timestamp":1761757804543,"version":"build-2065373602"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T00:00:00Z","timestamp":1489708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2017,6]]},"abstract":"\n Objective<\/jats:title>\n \n To compare stone composition and serum\/urine biochemistries in stone formers with multiple sclerosis (\n MS<\/jats:styled-content>\n ) against stone formers without\n MS<\/jats:styled-content>\n and to examine the association between mobility, methods of bladder emptying, and stone formation.\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n In this retrospective case\u2010control study, we identified patients diagnosed with\n MS<\/jats:styled-content>\n and kidney stone disease who were seen at our institution between 2001 and 2016. For the first part of the study, up to two controls (stone formers without a history of\n MS<\/jats:styled-content>\n ) were identified for each case and matched on age, body mass index, and sex. For the second part of this study, matched controls (\n MS<\/jats:styled-content>\n patients without a history of stones) were identified in a 1:1 ratio in a similar fashion. Results of 24\u2010h urine biochemistry studies, stone compositions, serum laboratory measures, medications, history of stone surgeries, mobility, and method of bladder emptying were collected.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In all, 587 patients were identified who had both\n MS<\/jats:styled-content>\n and a history of stone disease. Of these, 118 patients had a stone composition available. When compared to matched controls, patients with\n MS<\/jats:styled-content>\n were significantly more likely to have calcium phosphate stones (42% vs 15%,\n P<\/jats:italic>\n < 0.001) and struvite stones (8% vs 3%,\n P<\/jats:italic>\n = 0.03) and less likely to have calcium oxalate monohydrate stones (39% vs 64%,\n P<\/jats:italic>\n < 0.001). Among those patients with a composition available, those with\n MS<\/jats:styled-content>\n were more likely to have undergone a percutaneous nephrolithotomy (\n PCNL<\/jats:styled-content>\n ; 25% vs 12%,\n P<\/jats:italic>\n = 0.005) or a cystolithopaxy (16% vs 3%,\n P<\/jats:italic>\n < 0.001) compared to their matched controls. In all, 61 patients had a complete 24\u2010h urinary stone panel. There were no significant differences in urinary\n pH<\/jats:styled-content>\n , volume, creatinine, calcium, citrate, oxalate, sodium, and uric acid as well as rates of hypocitraturia, hyperoxaluria, hypercalciuria, and hyperuricosuria among patients with\n MS<\/jats:styled-content>\n . Use of intermittent straight catheterisation [\n ISC<\/jats:styled-content>\n ; odds ratio (\n OR<\/jats:styled-content>\n ) 3.50, 95% confidence interval (\n CI<\/jats:styled-content>\n ) 1.89\u20136.47];\n P<\/jats:italic>\n < 0.001] or an indwelling catheter (\n OR<\/jats:styled-content>\n 9.78, 95%\n CI<\/jats:styled-content>\n 4.81\u201319.88;\n P<\/jats:italic>\n < 0.001) for bladder emptying was significantly associated with stone disease. There was no association between level of mobility and stone disease (\n P<\/jats:italic>\n = 0.10).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Similar to findings seen in patients with spinal cord injuries, patients with\n MS<\/jats:styled-content>\n have a high incidence of calcium phosphate stones and struvite stones when compared with matched controls. Additionally, they were more likely to undergo\n PCNL<\/jats:styled-content>\n . The method of bladder management appears to be a risk factor in the development of stone disease. These findings suggest the importance of prompt treatment of urinary tract infections in this population and delay the use of\n ISC<\/jats:styled-content>\n , suprapubic tube, or an indwelling Foley, when possible.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.13820","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T09:38:56Z","timestamp":1487669936000},"page":"919-925","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Multiple sclerosis and nephrolithiasis: a matched\u2010case comparative study"],"prefix":"10.1111","volume":"119","author":[{"given":"Vishnu","family":"Ganesan","sequence":"first","affiliation":[{"name":"Cleveland Clinic Lerner College of Medicine Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen Min","family":"Chen","sequence":"additional","affiliation":[{"name":"Case Western Reserve University School of Medicine Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajat","family":"Jain","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Glickman Urological Kidney Institute Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shubha","family":"De","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Glickman Urological Kidney Institute Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoj","family":"Monga","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Glickman Urological Kidney Institute Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,17]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"470","article-title":"A UK consensus on the management of the bladder in multiple sclerosis","volume":"80","author":"Fowler CJ","year":"2009","journal-title":"J Neurol Neurosurg 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