{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:41:14Z","timestamp":1772066474019,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T00:00:00Z","timestamp":1499990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2017,11]]},"abstract":"\n Objectives<\/jats:title>\n \n To evaluate the efficacy and safety of collagenase clostridium histolyticum (\n CCH<\/jats:styled-content>\n ; Xiapex\n \u00ae<\/jats:sup>\n , Xiaflex\n \u00ae<\/jats:sup>\n ) in the treatment of Peyronie's disease (\n PD<\/jats:styled-content>\n ) using a new modified treatment protocol that aims at reducing the number of injections needed and reducing patient visits, thus reducing the duration and cost of treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n A prospective study of 53 patients with\n PD<\/jats:styled-content>\n who had treatment with\n CCH<\/jats:styled-content>\n at a single centre using a new modified protocol. The angle of curvature assessment after an intracavernosal injection of prostaglandin E1, the International Index of Erectile Function (\n IIEF<\/jats:styled-content>\n ) and Peyronie's Disease Questionnaire (\n PDQ<\/jats:styled-content>\n ) were completed at baseline and at week 12 (4 weeks after the last injection). The Global Assessment of Peyronie's disease (\n GAPD<\/jats:styled-content>\n ) questionnaire was completed at week 12. Under a penile block of 10\n mL<\/jats:styled-content>\n plain lignocaine 1%, a total of three intralesional injections of\n CCH<\/jats:styled-content>\n (0.9 mg) were given at 4\u2010weekly intervals using a new modified injection technique. In between injections patients used a combination of home modelling, stretching and a vacuum device on a daily basis to mechanically stretch the plaque. Investigator modelling was not performed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The mean (range) penile curvature at baseline was 54 (30\u201390)\u00b0. Of the 53 patients in the study, 51 patients (96.2%) had an improvement in the angel of curvature by a mean (range) of 17.36 (0\u201340)\u00b0 or 31.4 (0\u201357)% from baseline after three\n CCH<\/jats:styled-content>\n injections. The final mean (range) curvature was 36.9 (12\u201375)\u00b0 (\n P<\/jats:italic>\n < 0.001). There was an improvement in each of the\n IIEF<\/jats:styled-content>\n questionnaire domains, all three\n PDQ<\/jats:styled-content>\n domains and the\n GAPD<\/jats:styled-content>\n .\n CCH<\/jats:styled-content>\n was well tolerated by all patients with only mild and transient local adverse events.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The new shortened protocol using\n CCH<\/jats:styled-content>\n treatment is safe, effective, and cost efficient. The results of using only three\n CCH<\/jats:styled-content>\n injections according to this modified protocol are comparable to those of the clinical trials that used eight\n CCH<\/jats:styled-content>\n injections.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.13932","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T02:56:45Z","timestamp":1497409005000},"page":"717-723","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["Safety and effectiveness of collagenase clostridium histolyticum in the treatment of Peyronie's disease using a new modified shortened protocol"],"prefix":"10.1111","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5505-9291","authenticated-orcid":false,"given":"Amr","family":"Abdel Raheem","sequence":"first","affiliation":[{"name":"Andrology Department University College London Hospital and The Institute of Urology London and St Peter's Andrology Centre London UK"},{"name":"Andrology Department Cairo University Hospital Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Capece","sequence":"additional","affiliation":[{"name":"Andrology Department University College London Hospital and The Institute of Urology London and St Peter's Andrology Centre London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4065-0801","authenticated-orcid":false,"given":"Odunayo","family":"Kalejaiye","sequence":"additional","affiliation":[{"name":"Andrology Department University College London Hospital and The Institute of Urology London and St Peter's Andrology Centre London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarek","family":"Abdel\u2010Raheem","sequence":"additional","affiliation":[{"name":"Andrology Department University College London Hospital and The Institute of Urology London and St Peter's Andrology Centre London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Falcone","sequence":"additional","affiliation":[{"name":"Andrology Department University College London Hospital and The Institute of Urology London and St Peter's Andrology Centre London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Johnson","sequence":"additional","affiliation":[{"name":"Andrology Department University College London Hospital and The Institute of Urology London and St Peter's Andrology Centre London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver G.","family":"Ralph","sequence":"additional","affiliation":[{"name":"Andrology Department University College London Hospital and The Institute of Urology London and St Peter's Andrology Centre London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulio","family":"Garaffa","sequence":"additional","affiliation":[{"name":"Andrology Department 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