{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:14:43Z","timestamp":1791656083378,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T00:00:00Z","timestamp":1503014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370862"],"award-info":[{"award-number":["81370862"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2018,1]]},"abstract":"\n Objectives<\/jats:title>\n \n To investigate whether the voiding dysfunction caused by spinal cord injury (\n SCI<\/jats:styled-content>\n ) in rats can be improved by i.v. administration of the serotonin (5\u2010\n HT<\/jats:styled-content>\n )\n 2A\/2C<\/jats:sub>\n receptor agonist 2,5\u2010dimethoxy\u20104\u2010iodophenyl\u20102\u2010aminopropanehydrochloride (\n DOI<\/jats:styled-content>\n ), and to discuss whether the mechanism can be ascribed to 5\u2010\n HT<\/jats:styled-content>\n 2A<\/jats:sub>\n and 5\u2010\n HT<\/jats:styled-content>\n 2C<\/jats:sub>\n receptor upregulation in lumbosacral cord motoneurons.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n Female Sprague\u2013Dawley rats were divided into two groups (\n SCI<\/jats:styled-content>\n group vs normal control [\n NC<\/jats:styled-content>\n ] group). Under urethane anaesthesia, cystometry was performed to examine the variation in urodynamic variables before and after successive intrathecal (i.t.) administration of various doses of\n DOI<\/jats:styled-content>\n into the lumbosacral cord. Changes in 5\u2010\n HT<\/jats:styled-content>\n 2A<\/jats:sub>\n and \u2010\n 2C<\/jats:sub>\n receptors in the lumbosacral cord were also investigated using immunohistochemical staining and Western blot analysis.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Compared with\n NC<\/jats:styled-content>\n rats, the\n SCI<\/jats:styled-content>\n rats had higher bladder capacity and post\u2010void residual urine volume, and lower voiding efficiency. After\n SCI<\/jats:styled-content>\n ,\n DOI<\/jats:styled-content>\n improved voiding efficiency, probably via external urethral sphincter (\n EUS<\/jats:styled-content>\n ) activity. Immunohistochemical staining and Western blot analysis showed that 5\u2010\n HT<\/jats:styled-content>\n 2A<\/jats:sub>\n and \u2010\n 2C<\/jats:sub>\n receptors were upregulated in lumbosacral cord motoneurons.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n In rats with\n SCI<\/jats:styled-content>\n ,\n DOI<\/jats:styled-content>\n can improve voiding efficiency; this may be attributable to 5\u2010\n HT<\/jats:styled-content>\n 2A<\/jats:sub>\n and \u2010\n 2C<\/jats:sub>\n receptor upregulation in lumbosacral cord motoneurons controlling\n EUS<\/jats:styled-content>\n activity.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.13964","type":"journal-article","created":{"date-parts":[[2017,7,15]],"date-time":"2017-07-15T12:52:39Z","timestamp":1500123159000},"page":"145-154","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Chronic spinal cord injury causes upregulation of serotonin (5\u2010\n HT<\/scp>\n )\n 2A<\/sub>\n and 5\u2010\n HT<\/scp>\n 2C<\/sub>\n receptors in lumbosacral cord motoneurons"],"prefix":"10.1111","volume":"121","author":[{"given":"Nailong","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Urology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianshu","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Urology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjian","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Urology Third People's Hospital of Nanchang City Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baojun","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Urology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiemin","family":"Si","sequence":"additional","affiliation":[{"name":"Department of Urology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Urology Tongji Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl\u2010Erik","family":"Andersson","sequence":"additional","affiliation":[{"name":"Wake Forest Institute for Regenerative Medicine Wake Forest Baptist Medical Center Winston Salem NC 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