{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:17:18Z","timestamp":1785575838956,"version":"3.56.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,8,28]],"date-time":"2017-08-28T00:00:00Z","timestamp":1503878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008191","name":"Wings for Life","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008492","name":"Swiss Continence Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To evaluate if urinary continence in patients with refractory neurogenic detrusor overactivity (\n                      <jats:styled-content style=\"fixed-case\">NDO<\/jats:styled-content>\n                      ) incontinence after intradetrusor onabotulinumtoxinA injections is sufficient for appropriate outcome assessment or if urodynamic investigation (\n                      <jats:styled-content style=\"fixed-case\">UDI<\/jats:styled-content>\n                      ) is needed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      A consecutive series of 148 patients undergoing intradetrusor onabotulinumtoxinA injections for refractory\n                      <jats:styled-content style=\"fixed-case\">NDO<\/jats:styled-content>\n                      incontinence were prospectively evaluated. Patients underwent\n                      <jats:styled-content style=\"fixed-case\">UDI<\/jats:styled-content>\n                      before and at 6 weeks after onabotulinumtoxinA injections. The primary outcome was the prevalence of maximum storage detrusor pressure (Pdet\n                      <jats:sub>max<\/jats:sub>\n                      storage) of &gt;40 cmH\n                      <jats:sub>2<\/jats:sub>\n                      O in continent patients at 6 weeks after treatment. The secondary outcomes were treatment effects on other clinical and video\u2010urodynamic variables.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 6 weeks after intradetrusor onabotulinumtoxinA injections, 98 of the 148 patients (66%) with\n                      <jats:styled-content style=\"fixed-case\">NDO<\/jats:styled-content>\n                      incontinence were continent. Of these patients, 18 (18%, confidence interval 12\u201327%) had a Pdet\n                      <jats:sub>max<\/jats:sub>\n                      storage of &gt;40 cmH\n                      <jats:sub>2<\/jats:sub>\n                      O. Gender, underlying neurological disorder, and high Pdet\n                      <jats:sub>max<\/jats:sub>\n                      storage before treatment appear to increase the risk of poor urodynamic outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Urinary continence is not sufficient for outcome assessment after intradetrusor onabotulinumtoxinA injections, as high intravesical pressures threatening the upper urinary tract may be missed in a relevant proportion of continent patients. Therefore, we strongly recommend\n                      <jats:styled-content style=\"fixed-case\">UDI<\/jats:styled-content>\n                      as a routine part of the follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.13976","type":"journal-article","created":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T16:30:41Z","timestamp":1501777841000},"page":"848-854","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Intradetrusor onabotulinumtoxinA injections for refractory neurogenic detrusor overactivity incontinence: do we need urodynamic investigation for outcome assessment?"],"prefix":"10.1111","volume":"120","author":[{"given":"Miriam","family":"Koschorke","sequence":"first","affiliation":[{"name":"Neuro\u2010Urology Spinal Cord Injury Center and Research University of Z\u00fcrich Balgrist University Hospital Z\u00fcrich Switzerland"},{"name":"Department of Urology University Hospital Pedro Ernesto Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz","family":"Leitner","sequence":"additional","affiliation":[{"name":"Neuro\u2010Urology Spinal Cord Injury Center and Research University of Z\u00fcrich Balgrist University Hospital Z\u00fcrich Switzerland"},{"name":"Department of Urology University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Sadri","sequence":"additional","affiliation":[{"name":"Neuro\u2010Urology Spinal Cord Injury Center and Research University of Z\u00fcrich Balgrist University Hospital Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie C.","family":"Kn\u00fcpfer","sequence":"additional","affiliation":[{"name":"Neuro\u2010Urology Spinal Cord Injury Center and Research University of Z\u00fcrich Balgrist University Hospital Z\u00fcrich 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