{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T22:21:24Z","timestamp":1765232484343,"version":"build-2065373602"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T00:00:00Z","timestamp":1504569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To determine if multiparametric (mp) magnetic resonance imaging (\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      ) can identify significant apical disease, thereby informing decisions regarding preservation of the membranous urethra.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Men undergoing radical prostatectomy (\n                      <jats:styled-content style=\"fixed-case\">RP<\/jats:styled-content>\n                      ) between January 2012 and June 2016, who underwent a 12\u2010core transrectal ultrasonography\u2010guided systematic biopsy (\n                      <jats:styled-content style=\"fixed-case\">SB<\/jats:styled-content>\n                      ), preoperative 3\u2010Tesla\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      , and sectioning of the prostate specimen with tumour foci mapping, were extracted from a single surgeon's prospective longitudinal outcomes database. Apical\n                      <jats:styled-content style=\"fixed-case\">SB<\/jats:styled-content>\n                      and mp\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      lesion results were compared with regard to their ability to predict aggressive tumours in the prostatic apex (\n                      <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>\n                      ), defined as prostate cancer grade group &gt;1.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 100 men who met the eligibility criteria, 43 (43%) exhibited aggressive prostate cancer in the distal 5\u00a0mm of the apex. A Likert score &gt;2 in the apical one\u2010third of the\u00a0prostate was found to be more reliable than any cancer\u00a0found on apical\n                      <jats:styled-content style=\"fixed-case\">SB<\/jats:styled-content>\n                      at detecting aggressive cancer in\u00a0the apex. On multivariate regression analysis, which\u00a0included Likert score in the apex, age, prostate\u2010specific antigen (\n                      <jats:styled-content style=\"fixed-case\">PSA<\/jats:styled-content>\n                      ) level, prostate size and presence of any cancer on apical biopsy, only Likert score (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.005) and\n                      <jats:styled-content style=\"fixed-case\">PSA<\/jats:styled-content>\n                      level (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.025) were significant and\u00a0independent predictors of aggressive cancer in the distal apex.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The results of the study showed that\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      was superior to\n                      <jats:styled-content style=\"fixed-case\">SB<\/jats:styled-content>\n                      at identifying aggressive prostate cancer within the distal\n                      <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>\n                      and may be useful for planning the extent of apical preservation during\n                      <jats:styled-content style=\"fixed-case\">RP<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.13987","type":"journal-article","created":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T07:32:41Z","timestamp":1502695961000},"page":"239-243","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Multiparametric magnetic resonance imaging identifies significant apical prostate 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