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This review compared the efficacy of available treatments to provide prescribing guidance to healthcare professionals.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            This is the first review to compare the effectiveness of different osteoporotic treatments (bisphosphonates, denosumab, toremifene, and raloxifene) on\n                            <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>\n                            in patients with non\u2010metastatic prostate cancer on\n                            <jats:styled-content style=\"fixed-case\">ADT<\/jats:styled-content>\n                            using network meta\u2010analysis.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            Results suggest that all evaluated treatments are effective in improving\n                            <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>\n                            compared to placebo.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            Zoledronic acid (\n                            <jats:styled-content style=\"fixed-case\">ZA<\/jats:styled-content>\n                            ) was found to have a greater improvement in\n                            <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>\n                            compared to other active treatments at all three studied sites, except for risedronate, which had better\n                            <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>\n                            improvement compared to\n                            <jats:styled-content style=\"fixed-case\">ZA<\/jats:styled-content>\n                            at the femoral neck site in one small study.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Our study did not identify evidence that one drug is unequivocally more effective than another. All drugs appeared to be effective in reducing the rate of bone loss. Healthcare professionals should also consider patient preference, costs, and local availability as part of the decision process.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.14015","type":"journal-article","created":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T10:52:42Z","timestamp":1505731962000},"page":"17-28","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Systematic review and network meta\u2010analysis on the relative efficacy of osteoporotic medications: men with prostate cancer on continuous androgen\u2010deprivation therapy to reduce risk of fragility fractures"],"prefix":"10.1111","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4290-832X","authenticated-orcid":false,"given":"Yeesha","family":"Poon","sequence":"first","affiliation":[{"name":"The University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros","family":"Pechlivanoglou","sequence":"additional","affiliation":[{"name":"The University of Toronto Toronto ON Canada"},{"name":"Toronto Health Economic and Technology Assessment Collaborative Toronto ON Canada"},{"name":"The Hospital for Sick Children Toronto ON Canada"},{"name":"Institute of Health Policy Management and Evaluation Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabbir M.H.","family":"Alibhai","sequence":"additional","affiliation":[{"name":"The University of Toronto Toronto ON Canada"},{"name":"Toronto Health Economic and Technology Assessment Collaborative Toronto ON Canada"},{"name":"Institute of Health Policy Management and Evaluation Toronto ON Canada"},{"name":"University Health Network Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Naimark","sequence":"additional","affiliation":[{"name":"The University of Toronto Toronto ON Canada"},{"name":"Institute of Health Policy Management and Evaluation Toronto ON Canada"},{"name":"Sunnybrook Health Sciences Centre Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey S.","family":"Hoch","sequence":"additional","affiliation":[{"name":"The University of Toronto Toronto ON Canada"},{"name":"Institute of Health Policy Management and Evaluation Toronto ON Canada"},{"name":"Li Ka Shing Knowledge Institute of St. Michael's Hospital Toronto ON Canada"},{"name":"Department of Public Health Sciences University of California, Davis Sacramento CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Papadimitropoulos","sequence":"additional","affiliation":[{"name":"The University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary\u2010Ellen","family":"Hogan","sequence":"additional","affiliation":[{"name":"The University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray","family":"Krahn","sequence":"additional","affiliation":[{"name":"The University of Toronto Toronto ON Canada"},{"name":"Toronto Health Economic and Technology Assessment Collaborative Toronto ON Canada"},{"name":"Institute of Health Policy Management and Evaluation Toronto ON Canada"},{"name":"University Health Network Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,15]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Canadian Cancer Society.Prostate cancer statistics. 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