{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:26:15Z","timestamp":1770837975070,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,29]],"date-time":"2017-10-29T00:00:00Z","timestamp":1509235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2018,1]]},"abstract":"\n Objective<\/jats:title>\n \n To investigate the outcomes of patients with upper tract urothelial carcinoma (\n UTUC<\/jats:styled-content>\n ) with non\u2010definitive therapy, which currently remains unknown.\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n We used the Surveillance, Epidemiology, and End Results (\n SEER<\/jats:styled-content>\n ) database to identify individuals with a localised, histologically confirmed kidney\/renal pelvis and ureteric\n UC<\/jats:styled-content>\n . Survival analysis using the Kaplan\u2013Meier method was performed. A competing risk model evaluated the cumulative incidence and predictors of cancer\u2010specific mortality (\n CSM<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We identified 633 (7.6%) individuals who did not receive surgery. These individuals were significantly older (median age 81 vs 71 years,\n P<\/jats:italic>\n < 0.001) than surgically managed patients. The median overall survival (\n OS<\/jats:styled-content>\n ) was significantly shorter compared to the surgical cohort (1.9 vs 7.8 years,\n P<\/jats:italic>\n < 0.001). The 3\u2010year disease\u2010specific survival (\n DSS<\/jats:styled-content>\n ) for patients without surgery was significantly lower compared to those with surgery, at 73.7% vs 92.4%, respectively (\n P<\/jats:italic>\n < 0.001). The 3\u2010year\n DSS<\/jats:styled-content>\n for patients with high\u2010grade tumours was worse when compared to patients with low\u2010grade tumours, at 65.1% vs 82.9%, respectively (\n P<\/jats:italic>\n < 0.001). The 3\u2010year cumulative\n CSM<\/jats:styled-content>\n was 26.3%. On multivariable analysis, older age (hazard ratio [\n HR<\/jats:styled-content>\n ] 1.05,\n P<\/jats:italic>\n < 0.001) and high tumour grade (\n HR<\/jats:styled-content>\n 1.88,\n P<\/jats:italic>\n < 0.001) were predictors of worse outcomes.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In this population\u2010based cohort, 7.6% of patients with\n UTUC<\/jats:styled-content>\n were managed with a non\u2010definitive approach. The median\n OS<\/jats:styled-content>\n for the untreated cohort was significantly shorter compared to the surgical cohort (1.9 vs 7.8 years, respectively). These data may be helpful in counselling patients who are poor surgical candidates, as non\u2010definitive therapy may provide reasonable oncological outcomes.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.14042","type":"journal-article","created":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T11:36:37Z","timestamp":1507030597000},"page":"124-129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Survival outcomes for patients with localised upper tract urothelial carcinoma managed with non\u2010definitive treatment"],"prefix":"10.1111","volume":"121","author":[{"given":"Jamil S.","family":"Syed","sequence":"first","affiliation":[{"name":"Department of Urology Yale School of Medicine New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin A.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Urology Yale School of Medicine New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Suarez\u2010Sarmiento","sequence":"additional","affiliation":[{"name":"Department of Urology Yale School of Medicine New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katelyn","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Urology Yale School of Medicine New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Leapman","sequence":"additional","affiliation":[{"name":"Department of Urology Yale School of Medicine New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8480-8397","authenticated-orcid":false,"given":"Jay D.","family":"Raman","sequence":"additional","affiliation":[{"name":"Division of Urology Penn State Health Milton S. Hershey Medical Center Hershey PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2065-3570","authenticated-orcid":false,"given":"Brian","family":"Shuch","sequence":"additional","affiliation":[{"name":"Department of Urology Yale School of Medicine New Haven CT USA"},{"name":"Department of Radiology Yale School of Medicine New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21387"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.06.044"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2010.09675.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21354"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2015.1103638"},{"key":"e_1_2_8_7_1","first-page":"7369","article-title":"Critical analysis of 30 day complications following radical nephroureterectomy for upper tract urothelial carcinoma","volume":"21","author":"Lin YK","year":"2014","journal-title":"Can J Urol"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2013.06.015"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13556"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21278"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32455-2"},{"key":"e_1_2_8_12_1","unstructured":"National Cancer Institute Surveillance Research Program Surveillance Systems Branch.Surveillance Epidemiology and End Results (SEER) Program. 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