{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:08:49Z","timestamp":1792166929128,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2018,2]]},"abstract":"\n Objectives<\/jats:title>\n \n To investigate whether ureteroscopy (\n URS<\/jats:styled-content>\n ) before radical nephroureterectomy (\n RNU<\/jats:styled-content>\n ) for upper tract urothelial carcinomas (\n UTUC<\/jats:styled-content>\n s) has an impact on oncological outcomes.\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n We performed a systematic literature search of PubMed, Web of Science, and\n EMBASE<\/jats:styled-content>\n for citations published prior to September 2017 that described\n URS<\/jats:styled-content>\n performed on patients with\n UTUC<\/jats:styled-content>\n and conducted a standard meta\u2010analysis on survival outcomes.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Our meta\u2010analysis included eight eligible studies containing 3975 patients. The results were as follows: cancer\u2010specific survival (\n CSS<\/jats:styled-content>\n ; hazard ratio [\n HR<\/jats:styled-content>\n ] 0.76, 95% confidence interval [\n CI<\/jats:styled-content>\n ] 0.59\u20130.99;\n P<\/jats:italic>\n = 0.04), overall survival (\n OS<\/jats:styled-content>\n ;\n HR<\/jats:styled-content>\n 0.76, 95%\n CI<\/jats:styled-content>\n 0.48\u20131.21;\n P<\/jats:italic>\n = 0.24), recurrence\u2010free survival (\n RFS<\/jats:styled-content>\n ;\n HR<\/jats:styled-content>\n 0.89, 95%\n CI<\/jats:styled-content>\n 0.69\u20131.14;\n P<\/jats:italic>\n = 0.37), metastasis\u2010free survival (\n MFS<\/jats:styled-content>\n ;\n HR<\/jats:styled-content>\n 1.06, 95%\n CI<\/jats:styled-content>\n 0.82\u20131.36;\n P<\/jats:italic>\n = 0.66), and intravesical recurrence\u2010free survival (\n IRFS<\/jats:styled-content>\n ;\n HR<\/jats:styled-content>\n 1.51, 95%\n CI<\/jats:styled-content>\n 1.29\u20131.77;\n P<\/jats:italic>\n < 0.001). When excluding previous bladder tumour history, the result for\n IRFS<\/jats:styled-content>\n was a\n HR<\/jats:styled-content>\n of 1.81 (95%\n CI<\/jats:styled-content>\n 1.53\u20132.13;\n P<\/jats:italic>\n < 0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n This meta\u2010analysis indicated that\n URS<\/jats:styled-content>\n before\n RNU<\/jats:styled-content>\n did not have a negative impact on\n CSS<\/jats:styled-content>\n ,\n OS<\/jats:styled-content>\n ,\n RFS<\/jats:styled-content>\n , or\n MFS<\/jats:styled-content>\n in patients with\n UTUC<\/jats:styled-content>\n . However, patients were at higher risk of intravesical recurrence after\n RNU<\/jats:styled-content>\n when they had undergone\n URS<\/jats:styled-content>\n before\n RNU<\/jats:styled-content>\n . Further studies are needed to assess the effects of post\u2010\n URS<\/jats:styled-content>\n intravesical chemotherapy on intravesical recurrence.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.14053","type":"journal-article","created":{"date-parts":[[2017,10,15]],"date-time":"2017-10-15T10:46:38Z","timestamp":1508064398000},"page":"184-193","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":106,"title":["Impact of ureteroscopy before radical nephroureterectomy for upper tract urothelial carcinomas on oncological outcomes: a meta\u2010analysis"],"prefix":"10.1111","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7026-6937","authenticated-orcid":false,"given":"Run\u2010Qi","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Urology Peking University First Hospital Beijing China"},{"name":"Institute of Urology National Research Centre for Genitourinary Oncology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Urology Peking University First Hospital Beijing China"},{"name":"Institute of Urology National Research Centre for Genitourinary Oncology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geng\u2010Yan","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Urology Peking University First Hospital Beijing China"},{"name":"Institute of Urology National Research Centre for Genitourinary Oncology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology Peking University First Hospital Beijing China"},{"name":"Institute of Urology National Research Centre for Genitourinary Oncology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Urology Peking University First Hospital Beijing China"},{"name":"Institute of Urology National Research Centre for Genitourinary Oncology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7030-0856","authenticated-orcid":false,"given":"Xue\u2010Song","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology Peking University First Hospital Beijing China"},{"name":"Institute of Urology National Research Centre for Genitourinary Oncology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology Peking University First Hospital Beijing China"},{"name":"Institute of Urology National Research Centre for Genitourinary Oncology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Qun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Urology Peking University First Hospital Beijing China"},{"name":"Institute of Urology National Research Centre for Genitourinary Oncology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.06.044"},{"key":"e_1_2_7_3_1","unstructured":"Centre for Evidence\u2010based Medicine.Oxford Centre for Evidence\u2010based Medicine Levels of Evidence (March 2009). 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