{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:40:33Z","timestamp":1772160033100,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,9]],"date-time":"2018-01-09T00:00:00Z","timestamp":1515456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2018,4]]},"abstract":"\n Objective<\/jats:title>\n \n To investigate the efficacy of endoscopic ablation of Hunner lesions (\n HL<\/jats:styled-content>\n s) in patients with interstitial cystitis (\n IC<\/jats:styled-content>\n ) and to find predictors of early recurrence of\n HL<\/jats:styled-content>\n s.\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n A prospective study was performed of patients with Hunner type\n IC<\/jats:styled-content>\n who underwent transurethral ablation. We repeated endoscopic ablation when symptoms and\n HL<\/jats:styled-content>\n s recurred during the follow\u2010up period. The primary endpoint was recurrence\u2010free time. Secondary endpoints were a change in frequency, nocturia, and urgency episodes, and changes in visual analogue scale (\n VAS<\/jats:styled-content>\n ) pain scores and other symptom indices at follow\u2010up visits.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 72 patients were analysed. The median (range) follow\u2010up period was 29.5 (12.0\u201350.0) months. After primary ablation treatment,\n HL<\/jats:styled-content>\n s recurred in 75.0% (54\/72) of patients, and the median (\n sd<\/jats:sc>\n ) recurrence\u2010free time was 12.0 (1.6) months. Amongst the 54 patients with recurrence, 50 underwent a second ablation treatment.\n HL<\/jats:styled-content>\n s occurred in 44.0% (22\/50) of individuals after the second operation, and the median (\n sd<\/jats:sc>\n ) recurrence\u2010free time was 18.0 (5.1) months. Lower maximal cystometric capacity (odds ratio 1.01, 95% confidence interval 1.001\u20131.013) was the predictive factor for early recurrence. There were significant improvements in the\n VAS<\/jats:styled-content>\n pain scores, O'Leary\u2010Sant Interstitial Cystitis Symptom Index and Problem Index, Pelvic Pain and Urgency\/Frequency Patient Symptom Scale after treatment (all,\n P<\/jats:italic>\n < 0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Endoscopic ablation is an effective treatment option for\n HL<\/jats:styled-content>\n s and significantly reduces pain and improves voiding symptoms. Repeat ablation upon recurrence could help symptom control and bladder preservation only if the bladder capacity is maintained.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.14097","type":"journal-article","created":{"date-parts":[[2017,12,12]],"date-time":"2017-12-12T08:54:42Z","timestamp":1513068882000},"page":"659-666","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Therapeutic effects of endoscopic ablation in patients with Hunner type interstitial cystitis"],"prefix":"10.1111","volume":"121","author":[{"given":"Kwang Jin","family":"Ko","sequence":"first","affiliation":[{"name":"Department of Urology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunwoo","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Urology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon Seok","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Urology Center for Prostate Cancer Research Institute and Hospital of the National Cancer Center Goyang Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sin Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Urology Gyeongsang National University Hospital Jinju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Heon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Urology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0891-2488","authenticated-orcid":false,"given":"Kyu\u2010Sung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Urology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"},{"name":"Department of Medical Device Management and Research SAIHST Sungkyunkwan University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.13118"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)61602-1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.03.064"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22837"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2014.09.012"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.4111\/kju.2013.54.10.682"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.08.013"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.1178"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)60067-3"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001920070019"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-013-2155-2"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)49222-6"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143316"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13235"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbju.14097","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.14097","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T09:46:42Z","timestamp":1761731202000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.14097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,9]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/bju.14097"],"URL":"https:\/\/doi.org\/10.1111\/bju.14097","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.732285073.793540859","asserted-by":"object"}]},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,9]]},"assertion":[{"value":"2018-01-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}