{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T15:25:04Z","timestamp":1775748304268,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,1,21]],"date-time":"2018-01-21T00:00:00Z","timestamp":1516492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To describe the clinicopathological characteristics and prognosis of subsequent non\u2010muscle\u2010invasive bladder cancer (NMIBC) after radical nephroureterectomy (RNU) for upper urinary tract urothelial carcinoma (UTUC), and particularly its response to intravesical Bacillus Calmette\u2010Gu\u00e9rin (BCG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>An observational study was conducted in 1463 patients with UTUC who had undergone RNU and in 1555 patients with primary NMIBC. Of the 1463 patients with UTUC, 256 (17%) subsequently developed NMIBC (UTUC\u2010NMIBC group) and were available for the analysis. The clinicopathological background and outcomes, including intravesical recurrence\u2010free survival and bladder progression\u2010free survival, were compared between the patients with UTUC\u2010NMIBC and the patients with primary NMIBC treated with intravesical BCG. Propensity score matching was performed to adjust for the potential differences in the backgrounds of the two groups. To validate the utility of the CUETO scoring model in the UTUC\u2010NMIBC group, risk scores were calculated and compared with the published probabilities for recurrence and progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with the unadjusted primary NMIBC group (\n                      <jats:italic>n<\/jats:italic>\n                      = 352), the UTUC\u2010NMIBC group (\n                      <jats:italic>n<\/jats:italic>\n                      = 75) were found to have a worse prognosis for intravesical recurrence and progression, before propensity score matching. After propensity score matching for potential confounding factors, however, a worse prognosis was observed only for intravesical recurrence. The validation test of the CUETO scoring model for the UTUC\u2010NMIBC group showed a significant difference in the rate of intravesical recurrence and progression for the 0\u20134 and 5\u20136 score groups between the UTUC\u2010NMIBC group and the CUETO risk table reference data.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Compared with the primary NMIBC group, the UTUC\u2010NMIBC group had a worse prognosis after intravesical BCG, especially with regard to intravesical recurrence. This suggests that patients with UTUC\u2010NMIBC are inherently poor responders to BCG exposure. An optimal treatment strategy and risk scoring model to select patients for adjuvant intravesical BCG, chemotherapy or immediate radical cystectomy should be established.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.14111","type":"journal-article","created":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T18:42:58Z","timestamp":1514400178000},"page":"764-773","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Outcomes of subsequent non\u2010muscle\u2010invasive bladder cancer treated with intravesical Bacillus Calmette\u2010Gu\u00e9rin after radical nephroureterectomy for upper urinary tract urothelial carcinoma"],"prefix":"10.1111","volume":"121","author":[{"given":"Makito","family":"Miyake","sequence":"first","affiliation":[{"name":"Department of Urology Nara Medical University Kashihara Nara 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