{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T18:17:08Z","timestamp":1781806628902,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T00:00:00Z","timestamp":1519689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100003896","name":"Henry M. Jackson Foundation","doi-asserted-by":"publisher","award":["Grant # HU0001\u201011\u20101\u2010 0023"],"award-info":[{"award-number":["Grant # HU0001\u201011\u20101\u2010 0023"]}],"id":[{"id":"10.13039\/100003896","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2018,5]]},"abstract":"\n Objectives<\/jats:title>\n \n To assess the association of testosterone replacement therapy (\n TRT<\/jats:styled-content>\n ) with thromboembolism, cardiovascular disease (stroke, coronary artery disease and heart failure) and obstructive sleep apnoea (\n OSA<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A cohort of 3 422 male\n US<\/jats:styled-content>\n military service members, retirees and their dependents, aged 40\u201364 years, was identified, who were prescribed\n TRT<\/jats:styled-content>\n between 2006 and 2010 for low testosterone levels. The men in this cohort were matched on a 1:1 basis for age and comorbidities to men without a prescription for\n TRT<\/jats:styled-content>\n . Event\u2010free survival and rates of thromboembolism, cardiovascular events and\n OSA<\/jats:styled-content>\n were compared between men using\n TRT<\/jats:styled-content>\n and the control group, with a median follow\u2010up of 17 months.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n There was no difference in event\u2010free survival with regard to thromboembolism (\n P<\/jats:italic>\n = 0.239). Relative to controls, men using\n TRT<\/jats:styled-content>\n had improved cardiovascular event\u2010free survival (\n P<\/jats:italic>\n = 0.004), mainly as a result of lower incidence of coronary artery disease (\n P<\/jats:italic>\n = 0.008). The risk of\n OSA<\/jats:styled-content>\n was higher in\n TRT<\/jats:styled-content>\n users (2\u2010year risk 16.5% [95% confidence interval 15.1\u201318.1] in the\n TRT<\/jats:styled-content>\n group vs 12.7% [11.4\u201314.1] in the control group.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n This study adds to growing evidence that the cardiovascular risk associated with\n TRT<\/jats:styled-content>\n may be lower than once feared. The elevated risk of\n OSA<\/jats:styled-content>\n in men using\n TRT<\/jats:styled-content>\n is noteworthy.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.14149","type":"journal-article","created":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T23:56:39Z","timestamp":1517356599000},"page":"811-818","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Impact of testosterone replacement therapy on thromboembolism, heart disease and obstructive sleep apnoea in men"],"prefix":"10.1111","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0049-8529","authenticated-orcid":false,"given":"Alexander P.","family":"Cole","sequence":"first","affiliation":[{"name":"Center for Surgery and Public Health Brigham and Women's Hospital Harvard Medical School Boston MA USA"},{"name":"Division of Urological Surgery Brigham and Women's Hospital Harvard Medical School Boston MA 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R.","family":"Lipsitz","sequence":"additional","affiliation":[{"name":"Center for Surgery and Public Health Brigham and Women's Hospital Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kathrins","sequence":"additional","affiliation":[{"name":"Division of Urological Surgery Brigham and Women's Hospital Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Learn","sequence":"additional","affiliation":[{"name":"Department of Surgery Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7116-8674","authenticated-orcid":false,"given":"Maxine","family":"Sun","sequence":"additional","affiliation":[{"name":"Center for Surgery and Public Health Brigham and Women's Hospital Harvard Medical School 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