{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:45:47Z","timestamp":1787013947157,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:00:00Z","timestamp":1522972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2018,8]]},"abstract":"\n Objectives<\/jats:title>\n \n To determine, in a prospective, multicentre setting, the prevalence of fluoroquinolone\u2010resistant (\n FQ<\/jats:styled-content>\n \u2010R) and extended\u2010spectrum \u03b2\u2010lactamase (\n ESBL<\/jats:styled-content>\n )\u2010producing\n Escherichia coli<\/jats:italic>\n (\n E. coli<\/jats:italic>\n ) strains in men undergoing transrectal ultrasonography\u2010guided prostate biopsy (\n TRUS<\/jats:styled-content>\n \u2010Bx) in Finland; and to survey the associated risk factors for having the previously mentioned strains.\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n This is a substudy of the trial investigating the role of magnetic resonance imaging (\n MRI<\/jats:styled-content>\n ) in prostate cancer diagnosis (Improved Prostate Cancer Diagnosis \u2013 Combination of Magnetic Resonance Imaging Targeted Biopsies and Biomarkers Multi\u2010institutional Study [multi\u2010\n IMPROD<\/jats:styled-content>\n ],\n NCT<\/jats:styled-content>\n 02241122). In all, 359 patients from four study centres were recruited to this prospective study. After having signed the informed consent form, these men with suspicion of prostate cancer completed a detailed questionnaire on their medical, smoking, and travelling history, as well as their recent use of antibiotics. After the bi\u2010parametric\n MRI<\/jats:styled-content>\n scan,\n TRUS<\/jats:styled-content>\n \u2010Bx was taken and a rectal swab sample was collected and cultured for determining the antimicrobial susceptibility profile of\n E. coli<\/jats:italic>\n strains. The potential risk factors for having\n FQ<\/jats:styled-content>\n \u2010R or third\u2010generation cephalosporin\u2010resistant (3\n GC<\/jats:styled-content>\n \u2010R)\n E. coli<\/jats:italic>\n strains were analysed using univariate and multivariate logistic regression analysis.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The percentage of\n FQ<\/jats:styled-content>\n \u2010R and 3\n GC<\/jats:styled-content>\n \u2010R\n E. coli<\/jats:italic>\n strains amongst the study population was 13% and 8%, respectively. Amongst patients having\n E. coli<\/jats:italic>\n strains, the rate of\n FQ<\/jats:styled-content>\n \u2010R and 3\n GC<\/jats:styled-content>\n \u2010R strains was 14% and 8%, respectively. Of the 3\n GC<\/jats:styled-content>\n \u2010R\n E. coli<\/jats:italic>\n strains, 62% proved to be\n ESBL<\/jats:styled-content>\n \u2010producers and 88% were also\n FQ<\/jats:styled-content>\n \u2010R. In multivariate analysis, international travel during the preceding year significantly increased the risk of having a\n FQ<\/jats:styled-content>\n \u2010R\n E. coli<\/jats:italic>\n strain (odds ratio [\n OR<\/jats:styled-content>\n ] 3.592,\n P<\/jats:italic>\n = 0.001) and, unexpectedly, use of antibiotics during the previous year significantly decreased this risk (\n OR<\/jats:styled-content>\n 0.442,\n P<\/jats:italic>\n = 0.035). No significant risk factors for having 3\n GC<\/jats:styled-content>\n \u2010R\n E. coli<\/jats:italic>\n were identified.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The occurrence of intestinal\n FQ<\/jats:styled-content>\n \u2010R and\/or 3\n GC<\/jats:styled-content>\n \u2010R (potentially\n ESBL<\/jats:styled-content>\n \u2010producing)\n E. coli<\/jats:italic>\n strains in men undergoing\n TRUS<\/jats:styled-content>\n \u2010Bx in Finland is notable. The finding is consistent with the global increase in antimicrobial resistance. International travel appears to be an indisputable risk factor for having intestinal\n FQ<\/jats:styled-content>\n \u2010R\n E. coli<\/jats:italic>\n strains. The contemporary antimicrobial resistance situation should be taken into account in the care of post\u2010\n TRUS<\/jats:styled-content>\n \u2010Bx infections.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.14198","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T07:07:46Z","timestamp":1521097666000},"page":"203-210","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Antibiotic susceptibility of intestinal\n Escherichia coli<\/i>\n in men undergoing transrectal prostate biopsies: a prospective, registered, multicentre study"],"prefix":"10.1111","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0997-9668","authenticated-orcid":false,"given":"Juha","family":"Knaapila","sequence":"first","affiliation":[{"name":"Department of Urology Turku University Hospital Turku Finland"},{"name":"Department of Urology University of Turku Turku Finland"},{"name":"Department 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Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto","family":"Ettala","sequence":"additional","affiliation":[{"name":"Department of Urology Turku University Hospital Turku Finland"},{"name":"Department of Urology University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esa","family":"K\u00e4hk\u00f6nen","sequence":"additional","affiliation":[{"name":"Department of Urology Turku University Hospital Turku Finland"},{"name":"Department of Urology University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarja","family":"Lamminen","sequence":"additional","affiliation":[{"name":"Department of Urology Turku University Hospital Turku Finland"},{"name":"Department of Urology University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjo","family":"Sepp\u00e4nen","sequence":"additional","affiliation":[{"name":"Department Urology Satakunta 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