{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T04:24:42Z","timestamp":1785039882059,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,6,10]],"date-time":"2018-06-10T00:00:00Z","timestamp":1528588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"PROCEPT BioRobotics"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To present early safety and feasibility data from a multicentre prospective study (WATER II) of aquablation in the treatment of symptomatic men with large\u2010volume benign prostatic hyperplasia (\n                      <jats:styled-content style=\"fixed-case\">BPH<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Between September and December 2017, 101 men with moderate\u2010to\u2010severe\n                      <jats:styled-content style=\"fixed-case\">BPH<\/jats:styled-content>\n                      symptoms and prostate volume of 80\u2013150 mL underwent aquablation in a prospective multicentre international clinical trial. Baseline demographics and standardized postoperative management variables were carefully recorded in a central independently monitored database. Surgeons answered analogue scale questionnaires on intra\u2010operative technical factors and postoperative management. Adverse events up to 1 month were adjudicated by an independent clinical events committee.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean (range) prostate volume was 107 (80\u2013150) mL. The mean (range) operating time was 37 (15\u201397) min and aquablation resection time was 8 (3\u201315) min. Adequate adenoma resection was achieved with a single pass in 34 patients and with additional passes in 67 patients (mean 1.8 treatment passes), all in a single operating session. Haemostasis was achieved using either a Foley balloon catheter placed in the bladder under traction (\n                      <jats:italic>n<\/jats:italic>\n                      = 98, mean duration 18 h) or direct tamponade using a balloon inflated in the prostate fossa (\n                      <jats:italic>n<\/jats:italic>\n                      = 3, mean duration 15 h). No patient required electrocautery for haemostasis at the time of the primary procedure. The mean length of stay after the procedure was 1.6 days (range same day to 6 days). The Clavien\u2013Dindo grade \u22652 event rate observed at 1 month was 29.7%. Bleeding complications were recorded in 10 patients (9.9%) during the index procedure hospitalization prior to discharge, and included six (5.9%) peri\u2010operative transfusions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Aquablation is feasible and safe in treating men with men with large prostates (80\u2013150 mL). The 6\u2010month efficacy data are being accrued and will be presented in future publications (ClinicalTrials.gov number,\n                      <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>\n                      03123250).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.14360","type":"journal-article","created":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T15:52:36Z","timestamp":1524671556000},"page":"106-112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["WATER II (80\u2013150 mL) procedural outcomes"],"prefix":"10.1111","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3744-8234","authenticated-orcid":false,"given":"Mihir","family":"Desai","sequence":"first","affiliation":[{"name":"Institute of Urology University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mo","family":"Bidair","sequence":"additional","affiliation":[{"name":"San Diego Clinical Trials San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2679-2635","authenticated-orcid":false,"given":"Naeem","family":"Bhojani","sequence":"additional","affiliation":[{"name":"University of Montreal Hospital Centre University of Montr\u00e9al Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Trainer","sequence":"additional","affiliation":[{"name":"Adult Paediatric Urology and Urogynecology, P.C. Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Arther","sequence":"additional","affiliation":[{"name":"Adult Paediatric Urology and Urogynecology, P.C. Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Kramolowsky","sequence":"additional","affiliation":[{"name":"Virginia Urology Richmond VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Doumanian","sequence":"additional","affiliation":[{"name":"Institute of Urology University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean","family":"Elterman","sequence":"additional","affiliation":[{"name":"University Health Network University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Ronald P.","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Albany Medical College Albany NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Lingeman","sequence":"additional","affiliation":[{"name":"Indiana University Health Physicians Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Krambeck","sequence":"additional","affiliation":[{"name":"Indiana University Health Physicians Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg","family":"Eure","sequence":"additional","affiliation":[{"name":"Urology of Virginia Virginia Beach VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopal","family":"Badlani","sequence":"additional","affiliation":[{"name":"Wake Forest School of Medicine Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8874-9483","authenticated-orcid":false,"given":"Mark","family":"Plante","sequence":"additional","affiliation":[{"name":"University of Vermont Medical Centre Burlington VT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Uchio","sequence":"additional","affiliation":[{"name":"VA Long Beach Healthcare System Long Beach CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Gin","sequence":"additional","affiliation":[{"name":"VA Long Beach Healthcare System Long Beach CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Goldenberg","sequence":"additional","affiliation":[{"name":"University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Paterson","sequence":"additional","affiliation":[{"name":"University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"So","sequence":"additional","affiliation":[{"name":"University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitch","family":"Humphreys","sequence":"additional","affiliation":[{"name":"Mayo Clinic Arizona Scottsdale AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Roehrborn","sequence":"additional","affiliation":[{"name":"Department of Urology UT Southwestern Medical Centre University of Texas Southwestern Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Motola","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin C.","family":"Zorn","sequence":"additional","affiliation":[{"name":"University of Montreal Hospital Centre University of Montr\u00e9al Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,10]]},"reference":[{"issue":"1","key":"e_1_2_7_2_1","first-page":"60","article-title":"Prostatectomy for benign prostate disease: open, laparoscopic and robotic techniques","volume":"22","author":"Ferretti M","year":"2015","journal-title":"Can J Urol"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2015.06.048"},{"key":"e_1_2_7_4_1","unstructured":"American Urological Association \u2013 Adult Urodynamics: AUA\/SUFU Guideline 2012. 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