{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T14:59:05Z","timestamp":1792421945154,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T00:00:00Z","timestamp":1528329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2019,1]]},"abstract":"\n Objectives<\/jats:title>\n \n To determine the outcomes of complete surgical resection of T4 prostate cancer after inductive androgen\u2010deprivation therapy (\n ADT<\/jats:styled-content>\n ), as inductive\n ADT<\/jats:styled-content>\n and subsequent radical prostatectomy (\n RP<\/jats:styled-content>\n ) is not recommended by any guideline yet.\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n A monocentric\n RP<\/jats:styled-content>\n database was queried for patients initially diagnosed with T4 prostate cancer, considered primarily as inoperable because of a fixed mass defined by rectal examination in combination with high\n PSA<\/jats:styled-content>\n level and\/or large foci of biopsy confirmed undifferentiated prostate cancer. Treatment consisted of primary\n ADT<\/jats:styled-content>\n until\n PSA<\/jats:styled-content>\n nadir with consecutive\n RP<\/jats:styled-content>\n . Patients underwent retropubic\n RP<\/jats:styled-content>\n (\n RRP<\/jats:styled-content>\n ) or robot\u2010assisted laparoscopic\n RP<\/jats:styled-content>\n (\n RALP<\/jats:styled-content>\n ) after inductive\n ADT<\/jats:styled-content>\n until achievement of the\n PSA<\/jats:styled-content>\n nadir, which is in general reached after 6\u20137\u00a0months. The intraoperative course and complications were analysed. Finally, Kaplan\u2013Meier estimates were calculated for overall survival (\n OS<\/jats:styled-content>\n ) and prostate cancer\u2010specific survival (\n PCSS<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We retrospectively identified 116 patients treated between 2000 and 2014. At diagnosis, the median (range)\n PSA<\/jats:styled-content>\n level was 37.6 (2.44\u2013284) ng\/mL. The preoperative median (range)\n PSA<\/jats:styled-content>\n after inductive\n ADT<\/jats:styled-content>\n was 0.73 (0.01\u201334) ng\/mL. Thereafter, patients underwent\n RRP<\/jats:styled-content>\n or, since 2006,\n RALP<\/jats:styled-content>\n . The median (95% confidence interval)\n OS<\/jats:styled-content>\n was 156 (118.9\u2013193.1) months. The\n PCSS<\/jats:styled-content>\n at 150\u00a0months was 82%.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Surgical therapy of primarily inoperable prostate cancer is feasible and safe after inductive\n ADT<\/jats:styled-content>\n . The\n OS<\/jats:styled-content>\n of this cohort seems comparable with results described for patients with primary operable high\u2010risk prostate cancer.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.14393","type":"journal-article","created":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T13:50:08Z","timestamp":1526565008000},"page":"58-64","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Radical prostatectomy in T4 prostate cancer after inductive androgen deprivation: results of a single\u2010institution series with long\u2010term follow\u2010up"],"prefix":"10.1111","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8867-7870","authenticated-orcid":false,"given":"Turkan","family":"Hajili","sequence":"first","affiliation":[{"name":"Department of Urology and Pediatric Urology Saarland University Homburg\/Saar 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