{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:55:45Z","timestamp":1790621745261,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,6,20]],"date-time":"2018-06-20T00:00:00Z","timestamp":1529452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To build a nomogram able to predict treatment success after collagenase\n                      <jats:italic>Clostridium histolyticum<\/jats:italic>\n                      (CCH) for Peyronie's disease (PD).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Between November 2016 and November 2017, we enrolled 135 patients with PD into a multicentre single\u2010arm prospective study. All patients enrolled received CCH treatment. Success of therapy was defined as a decrease in penile curvature (PC) of \u226520\u00b0 from baseline. Treatment satisfaction was assessed using a scale from 1 to 10, and high satisfaction was arbitrarily defined as a score of \u22658. Calcification level was classified as: absence of calcification; low perilesional calcification; and high calcification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median (interquartile range [IQR]) patient age was 56.0 (45.0\u201365.0) years and the median (IQR) was PC was 30 (30.0\u201360.0)\u00b0. After the treatment protocol, we observed a significant median change in PC of \u221220.0\u00b0 (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01). The median (IQR) PC improvement was 44 (28.0\u201367.0)%. Overall median (IQR) satisfaction score was 8.0 (7.0\u20139.0). Treatment efficacy was reported in a total of 77 patients (57.04%). When analysing factors associated with PC improvement after treatment, we found that baseline PC (odds ratio [OR] 1.14;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01), basal plaque (OR 64.27;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01), low calcification (OR 0.06;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01) and high calcification (OR 0.03;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01) were significant predictors of PC improvement. The c\u2010index for the model was 0.93.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with longer PD duration, greater baseline PC and basal plaque location had a greater chance of treatment success. These results could be applied to clinical practice before external validation of our nomogram.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.14410","type":"journal-article","created":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T19:24:15Z","timestamp":1527103455000},"page":"680-687","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Predictors of treatment success after collagenase\n                    <i>Clostridium histolyticum<\/i>\n                    injection for Peyronie's disease: development of a nomogram from a multicentre single\u2010arm, non\u2010placebo controlled clinical study"],"prefix":"10.1111","volume":"122","author":[{"given":"Andrea","family":"Cocci","sequence":"first","affiliation":[{"name":"Department of Urology Careggi Hospital University of Florence Florence 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