{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T21:06:42Z","timestamp":1786223202014,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T00:00:00Z","timestamp":1532649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2017R1A2B4005876"],"award-info":[{"award-number":["2017R1A2B4005876"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the effects of 50\u00a0mg mirabegron once daily for ureteric stent\u2010related discomfort after ureteroscopic procedures by conducting a multicentre randomized study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      A total of 100 patients with indwelling ureteric stents after ureteroscopic stone removal or retrograde intrarenal surgery (\n                      <jats:styled-content style=\"fixed-case\">RIRS<\/jats:styled-content>\n                      ) were randomized 1:1 to receive either no treatment or mirabegron during the stenting period. At the time of stent removal, the validated Ureteral Stent Symptom Questionnaire (\n                      <jats:styled-content style=\"fixed-case\">USSQ<\/jats:styled-content>\n                      ), International Prostate Symptom Score (\n                      <jats:styled-content style=\"fixed-case\">IPSS<\/jats:styled-content>\n                      ), total amount of analgesics administered, and post\u2010voiding residual urine volume were reported for each patient.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 96 patients were enrolled for analysis\n                      <jats:bold>.<\/jats:bold>\n                      The postoperative\n                      <jats:styled-content style=\"fixed-case\">USSQ<\/jats:styled-content>\n                      body pain score (21.96 vs 13.96;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.007) and overall pain score (5.58 vs 2.83;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.002) were lower in the mirabegron group than in the control group. The\n                      <jats:styled-content style=\"fixed-case\">USSQ<\/jats:styled-content>\n                      urinary symptom scores (32.58 vs 27.92;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.582) and\n                      <jats:styled-content style=\"fixed-case\">USSQ<\/jats:styled-content>\n                      general health score (17.71 vs 14.00;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.281) were also lower in the mirabegron group, but the difference was not significant. Postoperative\n                      <jats:styled-content style=\"fixed-case\">IPSS<\/jats:styled-content>\n                      total scores and quality\u2010of\u2010life scores were lower in the mirabegron group, but the difference was not significant. The change in\n                      <jats:styled-content style=\"fixed-case\">IPSS<\/jats:styled-content>\n                      storage symptom score, however, was lower in the mirabegron group than in the control group (3.58 \u00b1 3.58 vs 1.83 \u00b1 4.39;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.035). Post\u2010void residual urine volume did not differ between the two groups (\n                      <jats:italic>P<\/jats:italic>\n                      &gt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The use of 50\u00a0mg mirabegron once daily has the potential to reduce ureteric stent\u2010related discomfort. Prospective larger\u2010scale, placebo\u2010controlled studies are warranted to further evaluate the beneficial effects of mirabegron on stent\u2010related symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.14416","type":"journal-article","created":{"date-parts":[[2018,5,26]],"date-time":"2018-05-26T10:19:26Z","timestamp":1527329966000},"page":"866-872","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Does mirabegron relieve ureteric stent\u2010related discomfort? 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