{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T14:40:55Z","timestamp":1761748855257,"version":"build-2065373602"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T00:00:00Z","timestamp":1532649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine whether penile blood pressure (PBP) can be used to identify patients who can benefit from tadalafil treatment, the correlation between PBP at baseline and changes in lower urinary tract symptoms (LUTS) induced by tadalafil treatment was studied prospectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      Patients with BPH who were poor responders to \u03b1\n                      <jats:sub>1<\/jats:sub>\n                      \u2010blockers and took tadalafil instead of an \u03b1\n                      <jats:sub>1<\/jats:sub>\n                      \u2010blocker were registered between 2014 and 2016. The patients were divided into two groups (low\u2010 and high\u2010PBP groups) using the median baseline PBP of 110 mmHg as the threshold. The changes in the International Prostate Symptom Score (IPSS) between before and at 4 and 12 weeks after tadalafil treatment were compared between the low\u2010 and high\u2010PBP groups. Multivariate analysis was performed to identify parameters associated with IPSS improvement with tadalafil treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In all, 51 patients were investigated. The IPSS in the low\u2010PBP group decreased immediately after the start of treatment, and there was significant improvement in the IPSS from baseline at 4 and 12 weeks after the start of treatment, whilst the IPSS in the high\u2010PBP group did not show significant changes. On multivariate analysis, PBP at baseline, anticholinergic drug use, and IPSS at baseline were significant predictors of a good IPSS response to tadalafil treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrated that PBP could reliably identify patients with BPH who could benefit from tadalafil treatment. Patients with low PBP could be better responders to tadalafil.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.14456","type":"journal-article","created":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T09:03:17Z","timestamp":1529398997000},"page":"124-129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Penile blood pressure is useful to identify candidates for tadalafil treatment in patients with lower urinary tract symptoms"],"prefix":"10.1111","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3278-7816","authenticated-orcid":false,"given":"Juntaro","family":"Koyama","sequence":"first","affiliation":[{"name":"Shirakawa Kousei General Hospital Shirakawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Kaiho","sequence":"additional","affiliation":[{"name":"Tohoku Medical and Pharmaceutical University Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihide","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"Tohoku University Graduate School of Medicine Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomonori","family":"Sato","sequence":"additional","affiliation":[{"name":"Shirakawa Kousei General Hospital Shirakawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Fukushi","sequence":"additional","affiliation":[{"name":"Shirakawa Kousei General Hospital Shirakawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Kyan","sequence":"additional","affiliation":[{"name":"Shirakawa Kousei General Hospital Shirakawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Arai","sequence":"additional","affiliation":[{"name":"Tohoku University Graduate School of Medicine Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,27]]},"reference":[{"volume-title":"Guidelines on the Treatment of Non\u2010neurogenic Male LUTS","author":"Gravas S","key":"e_1_2_8_2_1"},{"key":"e_1_2_8_3_1","first-page":"799","article-title":"Pelvic hemodynamics after aortoiliac reconstruction","volume":"86","author":"Queral LA","year":"1979","journal-title":"Surgery"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02471484"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000064923.29954.7e"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2008.07587.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-009-0449-8"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2011.02416.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.09.006"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.5980\/jpnjurol1989.93.669"},{"key":"e_1_2_8_11_1","unstructured":"Common Terminology Criteria for Adverse Events (CTCAE) version 4.0. 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