{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T09:35:00Z","timestamp":1771061700192,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,8,11]],"date-time":"2018-08-11T00:00:00Z","timestamp":1533945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Photocure ASA, Norway"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To evaluate blue\u2010light flexible cystoscopy (\n                      <jats:styled-content style=\"fixed-case\">BLFC<\/jats:styled-content>\n                      ) with hexaminolevulinate in the office surveillance of patients with non\u2010muscle\u2010invasive bladder cancer with a high risk of recurrence by assessing its impact on pain, anxiety, subjective value of the test and patient willingness to pay.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      A prospective, multicentre, phase\n                      <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\n                      study was conducted during which the Patient\u2010Reported Outcomes Measurement Information System (\n                      <jats:styled-content style=\"fixed-case\">PROMIS<\/jats:styled-content>\n                      ) Anxiety, Pain and \u2018Was It Worth It\u2019 questionnaires were administered at baseline, after surveillance with\n                      <jats:styled-content style=\"fixed-case\">BLFC<\/jats:styled-content>\n                      and after resection for those referred to the operating room. Comparisons of scores were performed between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 304 patients were enrolled, of whom 103 were referred for surgical examination. Of these, 63 were found to have histologically confirmed malignancy. Pain levels were low throughout the study. Anxiety levels decreased after\n                      <jats:styled-content style=\"fixed-case\">BLFC<\/jats:styled-content>\n                      (\u2206 = \u22122.6), with a greater decrease among those with negative pathology results (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.051). No differences in anxiety were noted based on gender,\n                      <jats:styled-content style=\"fixed-case\">BLFC<\/jats:styled-content>\n                      results, or test performance (true\u2010positive\/false\u2010positive). Most patients found\n                      <jats:styled-content style=\"fixed-case\">BLFC<\/jats:styled-content>\n                      \u2018worthwhile\u2019 (94%), would \u2018do it again\u2019 (94%) and \u2018would recommend it to others\u2019 (91%), with no differences based on\n                      <jats:styled-content style=\"fixed-case\">BLFC<\/jats:styled-content>\n                      results or test performance. Most patients undergoing\n                      <jats:styled-content style=\"fixed-case\">BLFC<\/jats:styled-content>\n                      (76%) were willing to pay out of pocket.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Anxiety decreased after\n                      <jats:styled-content style=\"fixed-case\">BLFC<\/jats:styled-content>\n                      in patients with negative pathology, including patients with false\u2010positive results. Most of the patients undergoing\n                      <jats:styled-content style=\"fixed-case\">BLFC<\/jats:styled-content>\n                      were willing to pay out of pocket, found the procedure worthwhile and would recommend it to others, irrespective of whether they had a positive\n                      <jats:styled-content style=\"fixed-case\">BLFC<\/jats:styled-content>\n                      result or whether this was false\u2010positive after surgery.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.14481","type":"journal-article","created":{"date-parts":[[2018,7,6]],"date-time":"2018-07-06T11:48:15Z","timestamp":1530877695000},"page":"35-41","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Patient\u2010reported outcomes of blue\u2010light flexible cystoscopy with hexaminolevulinate in the surveillance of bladder cancer: results from a prospective multicentre study"],"prefix":"10.1111","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3930-9817","authenticated-orcid":false,"given":"Angela B.","family":"Smith","sequence":"first","affiliation":[{"name":"University of North Carolina Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6224-9598","authenticated-orcid":false,"given":"Siamak","family":"Daneshmand","sequence":"additional","affiliation":[{"name":"University of Southern California Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Patel","sequence":"additional","affiliation":[{"name":"University of Oklahoma Oklahoma City OK USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamal","family":"Pohar","sequence":"additional","affiliation":[{"name":"Ohio State University Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edouard","family":"Trabulsi","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Medical College Thomas Jefferson University Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Woods","sequence":"additional","affiliation":[{"name":"University of North Carolina Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracy","family":"Downs","sequence":"additional","affiliation":[{"name":"University of Wisconsin Madison WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Huang","sequence":"additional","affiliation":[{"name":"New York University School of Medicine New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Taylor","sequence":"additional","affiliation":[{"name":"ME DeBakey VA Medical Center Houston TX 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