{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:04:33Z","timestamp":1790373873017,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T00:00:00Z","timestamp":1537488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001111","name":"Cancer Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001111","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000927","name":"Prostate Cancer Foundation of Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000927","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2019,2]]},"abstract":"\n Objectives<\/jats:title>\n \n To examine whether it is more efficacious to commence exercise medicine in men with prostate cancer at the onset of\n androgen\u2010deprivation therapy (ADT)<\/jats:styled-content>\n rather than later on during treatment to preserve bone and soft\u2010tissue composition, as\n ADT<\/jats:styled-content>\n results in adverse effects including: reduced bone mineral density (\n BMD<\/jats:styled-content>\n ), loss of muscle mass, and increased fat mass (FM).\n <\/jats:p>\n <\/jats:sec>\n \n Patients and methods<\/jats:title>\n \n In all, 104 patients with prostate cancer, aged 48\u201384\u00a0years initiating\n ADT,<\/jats:styled-content>\n were randomised to immediate exercise (\n IMEX<\/jats:styled-content>\n ,\n n<\/jats:italic>\n \u00a0=\u00a054) or delayed exercise (\n DEL<\/jats:styled-content>\n ,\n n<\/jats:italic>\n \u00a0=\u00a050) conditions. The former consisted of 6\u00a0months of supervised resistance\/aerobic\/impact exercise and the latter comprised 6\u00a0months of usual care followed by 6\u00a0months of the identical exercise programme. Regional and whole body\n BMD<\/jats:styled-content>\n , lean mass (LM), whole body FM and trunk FM, and appendicular skeletal muscle (\n ASM<\/jats:styled-content>\n ) were assessed by dual X\u2010ray absorptiometry, and muscle density by peripheral quantitative computed tomography at baseline, and at 6 and 12\u00a0months.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n There was a significant time effect (\n P<\/jats:italic>\n \u00a0<\u00a00.001) for whole body, spine and hip\n BMD<\/jats:styled-content>\n with a progressive loss in the\n IMEX<\/jats:styled-content>\n and\n DEL groups<\/jats:styled-content>\n , although lumbar spine\n BMD<\/jats:styled-content>\n was largely preserved in the\n IMEX<\/jats:styled-content>\n group at 6\u00a0months compared with the\n DEL<\/jats:styled-content>\n group (\u22120.4% vs \u22121.6%). LM,\n ASM<\/jats:styled-content>\n , and muscle density were preserved in the\n IMEX<\/jats:styled-content>\n group at 6\u00a0months, declined in the\n DEL<\/jats:styled-content>\n group at 6\u00a0months (\u22121.4% to \u22122.5%) and then recovered at 12\u00a0months after training. FM and trunk FM increased (\n P<\/jats:italic>\n \u00a0<\u00a00.001) over the 12\u2010month period in the\n IMEX<\/jats:styled-content>\n (7.8% and 4.5%, respectively) and\n DEL<\/jats:styled-content>\n groups (6.5% and 4.3%, respectively).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Commencing exercise at the onset of\n ADT<\/jats:styled-content>\n preserves lumbar spine\n BMD<\/jats:styled-content>\n , muscle mass, and muscle density. To avoid treatment\u2010related adverse musculoskeletal effects, exercise medicine should be prescribed and commenced at the onset of\n ADT<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.14505","type":"journal-article","created":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T21:32:02Z","timestamp":1537565522000},"page":"261-269","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Immediate versus delayed exercise in men initiating androgen deprivation: effects on bone density and soft tissue composition"],"prefix":"10.1111","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6381-1597","authenticated-orcid":false,"given":"Dennis R.","family":"Taaffe","sequence":"first","affiliation":[{"name":"Exercise Medicine Research Institute Edith Cowan University Joondalup Western Australia Australia"},{"name":"School of Medical and Health Sciences Edith Cowan University Joondalup 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