{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:13:13Z","timestamp":1790187193710,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T00:00:00Z","timestamp":1539648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To assess the long\u2010term efficacy and safety of polydimethylsiloxane injection (Macroplastique\n                      <jats:sup>\u00ae<\/jats:sup>\n                      , Cogentix Medical, Orangeburg, New York, USA) for the treatment of female stress urinary incontinence (SUI), with a minimum follow\u2010up of 3 years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      This is an observational analytical prospective cohort study conducted in a single uro\u2010gynaecological unit. All consecutive women with urodynamically confirmed pure\n                      <jats:styled-content style=\"fixed-case\">SUI<\/jats:styled-content>\n                      treated with the Macroplastique procedure, were included. Data regarding patient outcomes (International Consultation on Incontinence Questionnaire\u2013Short Form, Patient Global Impression of Improvement, and patient satisfaction scores), objective cure rates, and adverse events were collected during follow\u2010up. Uni\u2010 and multivariable analyses were performed to investigate outcomes. Multiple logistic regression was performed to identify factors involved in the risk of failure of the procedures or recurrence of\n                      <jats:styled-content style=\"fixed-case\">SUI<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In all, 85 women had the Macroplastique procedure. At the 3\u2010year follow\u2010up, all 85 (100%) patients were available for the evaluation. We did not find any significant change in the surgical outcomes during this time. At 3 years after surgery, 42 of 85 patients (49%) declared themselves cured (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.67). Similarly, at the 3\u2010year evaluation, 40 of 85 patients (47%) were objectively cured. There was no significant deterioration of objective cure rates over time (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.3). A history of radical pelvic surgery and a low surgeon's skill were significantly associated with the risk of failure of Macroplastique. The multivariate analysis confirmed these findings; a previous history of radical pelvic surgery and a low surgeon's skill independently predicted the subjective and objective failure of Macroplastique.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The 3\u2010year results of this study showed that Macroplastique could be an acceptable alternative for the treatment of\n                      <jats:styled-content style=\"fixed-case\">SUI<\/jats:styled-content>\n                      with stable results over time and a negligible complication rate.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.14550","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T12:10:07Z","timestamp":1537877407000},"page":"353-359","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Efficacy and safety of polydimethylsiloxane injection (Macroplastique\n                    <sup>\u00ae<\/sup>\n                    ) for the treatment of female stress urinary incontinence: results of a series of 85 patients with \u22653 years of follow\u2010up"],"prefix":"10.1111","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8534-646X","authenticated-orcid":false,"given":"Maurizio","family":"Serati","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Insubria Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Soligo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Buzzi Hospital \u2010ASST FBF Sacco University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4877-0640","authenticated-orcid":false,"given":"Andrea","family":"Braga","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology EOC \u2010 Beata Vergine Hospital Mendrisio Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Cantaluppi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Insubria Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna C.","family":"Coluccia","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Insubria Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Di Dedda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Insubria Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Salvatore","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Unit Vita\u2010Salute San Raffaele University and IRCCS San Raffaele Hospital Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Cetin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Buzzi Hospital \u2010ASST FBF Sacco University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Ghezzi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Insubria Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Publication Committee of the Italian Society of Urodynamics","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-017-0828-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-009-0850-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.12.022"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.01.038"},{"key":"e_1_2_7_6_1","unstructured":"USA Food and Drug Administration (FDA).Medical Device Safety \u2013 Surgical Mesh. Available at:http:\/\/www.fda.gov\/MedicalDevices\/Safety\/AlertsandNotices\/ucm142636.htm#popsui. Accessed January 2011"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.03.048"},{"key":"e_1_2_7_8_1","unstructured":"Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR).Opinion on the safety of surgical meshes used in urogynecological surgery 2015. Available at:http:\/\/ec.europa.eu\/health\/scientific_committees\/emerging\/docs\/scenihr_o_049.pdfAccessed May 2016"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2015.03.025"},{"key":"e_1_2_7_10_1","first-page":"CD003881","article-title":"Urethral injection therapy for urinary incontinence in women","volume":"7","author":"Kirchin V","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-017-3278-7"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2016(02)08"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-012-1825-9"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2006.20.1082"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(96)70243-0"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.03.010"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10066"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-015-2808-4"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-009-0976-9"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20041"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2000.tb10409.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-011-1398-z"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.379"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20440"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2011.01.016"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-013-2114-y"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-013-2090-2"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14136"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23007"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2009.11.022"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000152568.40199.a8"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbju.14550","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.14550","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T11:10:14Z","timestamp":1761736214000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.14550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,16]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1111\/bju.14550"],"URL":"https:\/\/doi.org\/10.1111\/bju.14550","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,16]]},"assertion":[{"value":"2018-10-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}