{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T22:10:32Z","timestamp":1792534232598,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:00:00Z","timestamp":1540339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2019,4]]},"abstract":"\n Objectives<\/jats:title>\n \n To address challenges in the diagnosis and classification of storage lower urinary tract symptoms (\n LUTS<\/jats:styled-content>\n ), we sought to define the fundamental features of overactive bladder (\n OAB<\/jats:styled-content>\n ) and interstitial cystitis\/bladder pain syndrome (\n IC<\/jats:styled-content>\n \/\n BPS<\/jats:styled-content>\n ), two conditions with considerable symptomatic overlap. Through retrospective comparison of self\u2010reported symptoms in women with a range of clinical presentations and symptom severities, we have attempted to refine the diagnostic features of\n OAB<\/jats:styled-content>\n and\n IC<\/jats:styled-content>\n \/\n BPS<\/jats:styled-content>\n and to develop a novel clinical nomogram to improve patient screening and classification.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n We performed a univariate analysis comparing responses to the female Genitourinary Pain Index (\n fGUPI<\/jats:styled-content>\n ), the\n OAB<\/jats:styled-content>\n Questionnaire and O'Leary\u2013Sant Indices (the Interstitial Cystitis Symptom Index and Interstitial Cystitis Problem Index) in an initial cohort of 50 patients with\n OAB<\/jats:styled-content>\n , patients with\n IC<\/jats:styled-content>\n \/\n BPS<\/jats:styled-content>\n and control subjects. Only eight questions differed significantly between the\n IC<\/jats:styled-content>\n \/\n BPS<\/jats:styled-content>\n and\n OAB<\/jats:styled-content>\n groups; we used five unique questions and three measuring bother to generate a novel composite scoring system and nomogram that included urgency incontinence, bladder pain and symptomatic bother domains to differentiate these populations, which was validated in a second cohort of 150 patients. The addition of a self\u2010reported bother index resulted in the creation of a diagnostic algorithm to identify and classify\n LUTS<\/jats:styled-content>\n clusters across the total population.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n While all validated questionnaires could distinguish between controls and patients with storage\n LUTS<\/jats:styled-content>\n , no combined symptom scores differed significantly between the\n IC<\/jats:styled-content>\n \/\n BPS<\/jats:styled-content>\n and\n OAB<\/jats:styled-content>\n groups. These results are reflective of the prevalence of significant bladder pain (35%) in patients with\n OAB<\/jats:styled-content>\n and the presence of urge incontinence (25%) in patients with\n IC<\/jats:styled-content>\n \/\n BPS<\/jats:styled-content>\n . Only the\n fGUPI<\/jats:styled-content>\n pain domain scores differed between patients in the\n OAB<\/jats:styled-content>\n and\n IC<\/jats:styled-content>\n \/\n BPS<\/jats:styled-content>\n groups, but it was not accurate enough for diagnostic evaluation (68% accuracy). Our composite scores and nomogram gave a much\u2010improved diagnostic accuracy (94%) and demonstrated utility as a screening tool to identify storage\n LUTS<\/jats:styled-content>\n in patients presenting for unrelated complaints, e.g. microhaematuria.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n There is significant overlap of urinary tract symptoms between\n OAB<\/jats:styled-content>\n and\n IC<\/jats:styled-content>\n \/\n BPS<\/jats:styled-content>\n . We present a novel algorithm that provides a binary output capable of guiding clinical diagnosis. Future studies aimed at assessing the diagnostic value of novel classification schemes that address symptoms rather than specific diagnoses may improve patient prognosis.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.14568","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T12:18:40Z","timestamp":1537877920000},"page":"682-693","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Symptomatic overlap in overactive bladder and interstitial cystitis\/bladder pain syndrome: development of a new algorithm"],"prefix":"10.1111","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4192-7649","authenticated-orcid":false,"given":"A. Lenore","family":"Ackerman","sequence":"first","affiliation":[{"name":"Division of Urology Department of Surgery Cedars\u2013Sinai Medical Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Henry","family":"Lai","sequence":"additional","affiliation":[{"name":"Departments of Surgery (Urology) and Anesthesiology Washington University School of Medicine in St Louis St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja S.","family":"Parameshwar","sequence":"additional","affiliation":[{"name":"Division of Urology Department of Surgery Cedars\u2013Sinai Medical Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karyn S.","family":"Eilber","sequence":"additional","affiliation":[{"name":"Division of Urology Department of Surgery Cedars\u2013Sinai Medical Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer T.","family":"Anger","sequence":"additional","affiliation":[{"name":"Division of Urology Department of Surgery Cedars\u2013Sinai Medical Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.08427.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2012.04.004"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2014.20.2.130"},{"key":"e_1_2_7_5_1","unstructured":"NIH.Meeeting on Measurement of Urinary Symptoms. 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