{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:17:38Z","timestamp":1788880658458,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T00:00:00Z","timestamp":1559433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003946","name":"European Society for Sexual Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003946","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2019,8]]},"abstract":"\n Objective<\/jats:title>\n \n To investigate whether local injection of autologous adipose stromal vascular fraction (\n SVF<\/jats:styled-content>\n ) can prevent the development of fibrosis and elastosis in the tunica albuginea (\n TA<\/jats:styled-content>\n ) using a rat model of the acute phase of Peyronie's disease (\n PD<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A total of 24 male 12\u2010week\u2010old Sprague\u2013Dawley rats were divided into three equal groups: sham;\n PD<\/jats:styled-content>\n without treatment (transforming growth factor\u2010\u03b2 [\n TGF<\/jats:styled-content>\n \u2010\u03b2]); and\n PD<\/jats:styled-content>\n treated with\n SVF<\/jats:styled-content>\n 1\u00a0day after disease induction. Sham rats received two injections of vehicle into the\n TA<\/jats:styled-content>\n 1\u00a0day apart.\n TGF<\/jats:styled-content>\n \u2010\u03b2 rats received\n TGF<\/jats:styled-content>\n \u2010 \u03b21 injection and injection of vehicle 1\u00a0day later.\n SVF<\/jats:styled-content>\n rats received\n TGF<\/jats:styled-content>\n \u2010\u03b21 injection, followed by\n SVF<\/jats:styled-content>\n 1\u00a0day later. One month after treatment, all rats underwent measurement of intracavernosal pressure and mean arterial pressure during electrostimulation of the cavernous nerve. The rats were then killed and penises were harvested for histology and Western blot analysis.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Erectile function was moderately reduced in the\n TGF<\/jats:styled-content>\n \u2010\u03b2 group and was significantly improved after\n SVF<\/jats:styled-content>\n treatment (\n P<\/jats:italic>\n < 0.05).\n PD<\/jats:styled-content>\n rats developed areas of fibrosis with a significant upregulation of collagen\n III<\/jats:styled-content>\n , collagen I and elastin protein expression. These fibrotic changes were prevented when treated with\n SVF<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Local injection of\n SVF<\/jats:styled-content>\n may represent treatment for the acute phase of\n PD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.14570","type":"journal-article","created":{"date-parts":[[2018,9,29]],"date-time":"2018-09-29T07:04:48Z","timestamp":1538204688000},"page":"342-348","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Intratunical injection of stromal vascular fraction prevents fibrosis in a rat model of Peyronie's disease"],"prefix":"10.1111","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8046-1963","authenticated-orcid":false,"given":"Fabio","family":"Castiglione","sequence":"first","affiliation":[{"name":"Laboratory for Experimental Urology Organ Systems Department of Development and Regeneration University of Leuven Leuven Belgium"},{"name":"Institute of Urology University College of London Hospital London UK"},{"name":"Division of Oncology\/Unit of Urology Urological Research Institute IRCCS Ospedale San Raffaele Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petter","family":"Hedlund","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Pharmacology Lund University Lund Sweden"},{"name":"Division of Drug Research Department of Medical and Health Sciences Link\u00f6ping University Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Weyne","sequence":"additional","affiliation":[{"name":"Laboratory for Experimental Urology Organ Systems Department of Development and Regeneration University of Leuven Leuven 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