{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:45:49Z","timestamp":1787013949523,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\n                            To evaluate the 1\u2010year efficacy of chitosan membrane (ChiMe) application on the neurovascular bundles (\n                            <jats:styled-content style=\"fixed-case\">NVBs<\/jats:styled-content>\n                            ) after nerve\u2010sparing (\n                            <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>\n                            ) robot\u2010assisted radical prostatectomy (\n                            <jats:styled-content style=\"fixed-case\">RARP<\/jats:styled-content>\n                            ) in potency recovery rate.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>To compare the results with those of a contemporary cohort of patients who did not benefit from chitosan use.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      Patients in the ChiMe group were enrolled at our institution from July 2015 to September 2016 in a preliminary phase\n                      <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n                      study. All of them underwent\n                      <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">RARP<\/jats:styled-content>\n                      with ChiMe applied on the\n                      <jats:styled-content style=\"fixed-case\">NVB<\/jats:styled-content>\n                      s and were followed over time to complete a 1\u2010year follow\u2010up. The control group was composed of patients who underwent\n                      <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">RARP<\/jats:styled-content>\n                      at our institution without the application of ChiMe from January 2015. The patients were further classified into two groups based on the amount of nerves spared: Group A, comprised patients who underwent a monolateral or bilateral full\n                      <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>\n                      ; Group B, comprised patients in which a full\n                      <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>\n                      was not performed. The demographics, peri\u2010 and postoperative data, and complications were recorded and compared. Potency recovery was recorded for Group A vs Group B in both the ChiMe and the control groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In all, 136 patients were enrolled in the ChiMe group and 334 patients in the control group. There were no differences between groups in terms of baseline variables. Based on the amount of nerves preserved, 183 patients were included in Group A and 287 in Group B. Odds ratios at different time points showed that the only two factors influencing potency recovery were the amount of nerves preserved (Group A vs Group B) and the application or not of ChiMe on the\n                      <jats:styled-content style=\"fixed-case\">NVB<\/jats:styled-content>\n                      s spared. Comparing the ChiMe vs control groups at different time points, we found a statistically significant improvement in the potency recovery rate in the ChiMe group at 1\u00a0month (36.76% vs 25.88%;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.02) and 2\u00a0months (52.2% vs 39.22%;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.01) after surgery, showing a favourable trend at every time point of the entire follow\u2010up period, even if not significant after the second postoperative month. In Group A, the log\u2010rank test showed a statistically significant difference between the ChiMe vs control groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.02), in particular at 1 and 2\u00a0months after surgery (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.02 and\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.01, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The application of ChiMe on the\n                      <jats:styled-content style=\"fixed-case\">NVB<\/jats:styled-content>\n                      s resulted in a higher potency recovery rate at 1 and 2\u00a0months after a bilateral or monolateral full\n                      <jats:styled-content style=\"fixed-case\">NS\u2010RARP<\/jats:styled-content>\n                      . A trend of a higher and shorter potency recovery rate showed it to be favourable to use ChiMe, even in the cohort of patients who did not undergo a full\n                      <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>\n                      procedure.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.14583","type":"journal-article","created":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T15:27:21Z","timestamp":1539185241000},"page":"465-473","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Use of chitosan membranes after nerve\u2010sparing radical prostatectomy improves early recovery of sexual potency: results of a comparative study"],"prefix":"10.1111","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8567-6795","authenticated-orcid":false,"given":"Francesco","family":"Porpiglia","sequence":"first","affiliation":[{"name":"Division 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