{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T23:10:12Z","timestamp":1790118612817,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T00:00:00Z","timestamp":1542844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2019,4]]},"abstract":"\n Objectives<\/jats:title>\n \n To evaluate the efficacy and safety of a new penile traction device (\n PTD<\/jats:styled-content>\n ), \u2018Penimaster\n PRO<\/jats:styled-content>\n \u2019, in a group of patients with stable Peyronie's disease (\n PD<\/jats:styled-content>\n ) compared with a non\u2010intervention group in a multicentre study.\n <\/jats:p>\n <\/jats:sec>\n \n Material and Methods<\/jats:title>\n \n A total of 93 patients with chronic stable\n PD<\/jats:styled-content>\n (without erectile dysfunction, with no significant pain, and with a unidirectional curvature of at least 45\u00b0 being stable for > 3\u00a0months) were recruited and followed for a 12\u2010week period. Of these patients, 47 were randomly assigned to the Penimaster\n PRO<\/jats:styled-content>\n group (\n PG<\/jats:styled-content>\n ) and 46 to the non\u2010intervention group (\n NIG<\/jats:styled-content>\n ). Patients were asked to apply the\n PTD<\/jats:styled-content>\n 3\u20138\u00a0h a day for 12 consecutive weeks, with specific instructions regarding the progressive increase of traction force applied to the penis over time. The primary outcome of the study was the change in the degree of curvature measured in the fully erect state after intracavernosal injection of alprostadil at baseline, 1, 2 and 3\u00a0months. Other variables, such as the type of curvature, stretched penile length (\n SPL<\/jats:styled-content>\n ), Peyronie's Disease Questionnaire (\n PDQ<\/jats:styled-content>\n ) scores, erectile function domain of the International Index of Erectile function (\n IIEF<\/jats:styled-content>\n \u2010\n EF<\/jats:styled-content>\n ) score and adverse events (AEs) were also assessed in each visit.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Forty\u2010one patients in the\n PG<\/jats:styled-content>\n and 39 in the\n NIG<\/jats:styled-content>\n completed the study. There was an overall reduction in curvature of 31.2\u00b0 (\n P<\/jats:italic>\n < 0.001) at 12\u00a0weeks compared to baseline in the\n PG<\/jats:styled-content>\n , representing a 41.1% improvement from baseline, which significantly correlated with the number of daily hours the device was applied in a dose\u2010dependent manner. Those patients using the device < 4\u00a0h\/day experienced a reduction of 15\u00b0\u201325\u00b0 (mean 19.7\u00b0, 28.8% improvement;\n P<\/jats:italic>\n < 0.05), while patients using the device > 6\u00a0h\/day experienced greater curvature reduction, ranging from 20\u00b0 to 50\u00b0 (mean of 38.4\u00b0, 51.4% improvement;\n P<\/jats:italic>\n < 0.001). In contrast, no significant changes in curvature were observed in the\n NIG<\/jats:styled-content>\n . Furthermore,\n SPL<\/jats:styled-content>\n increased significantly in the\n PG<\/jats:styled-content>\n compared to baseline and compared with the\n NIG<\/jats:styled-content>\n , ranging from 0.5 to 3.0\u00a0cm (mean 1.8\u00a0cm;\n P<\/jats:italic>\n < 0.05). The\n IIEF<\/jats:styled-content>\n \u2010\n EF<\/jats:styled-content>\n score also improved in patients in the\n PG<\/jats:styled-content>\n (by a mean of 5 points). Mild AEs occurred in 43% of patients, such as local discomfort and glans numbness.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The use of the Penimaster\n PRO PTD<\/jats:styled-content>\n , a non\u2010invasive treatment, should be offered to patients with stable\n PD<\/jats:styled-content>\n for 3 consecutive months before performing any corrective surgery, as this provided a significant reduction in the curvature, an increase in penile length and a significant improvement of the symptoms and bother induced by\n PD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.14602","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T08:39:47Z","timestamp":1540543187000},"page":"694-702","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Penile traction therapy with the new device \u2018Penimaster\n PRO<\/scp>\n \u2019 is effective and safe in the stable phase of Peyronie's disease: a controlled multicentre study"],"prefix":"10.1111","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9194-0660","authenticated-orcid":false,"given":"Ignacio","family":"Moncada","sequence":"first","affiliation":[{"name":"Hospital Universitario Sanitas la Zarzuela Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramod","family":"Krishnappa","sequence":"additional","affiliation":[{"name":"Hospital Universitario Sanitas la Zarzuela Madrid Spain"},{"name":"NU Hospitals Bangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Romero","sequence":"additional","affiliation":[{"name":"Hospital Universitario 12 de Octubre Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Torremade","sequence":"additional","affiliation":[{"name":"Hospital Universitari de Bellvitge Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agustin","family":"Fraile","sequence":"additional","affiliation":[{"name":"Hospital Universitario Ramon y Cajal Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Ignacio","family":"Martinez\u2010Salamanca","sequence":"additional","affiliation":[{"name":"Hospital Universitario Puerta de Hierro Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartmut","family":"Porst","sequence":"additional","affiliation":[{"name":"Private Institute for Urology and Sexual Medicine Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Levine","sequence":"additional","affiliation":[{"name":"Rush University Medical Center Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,22]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"HatzimouratidisK GiulianoF MoncadaIet\u00a0al.EAU guidelines on Erectile dysfunction Premature Ejaculation Penile Curvature and Priapism. 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