{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:33:05Z","timestamp":1787319185533,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T00:00:00Z","timestamp":1549411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009230","name":"Landstinget i Uppsala l\u00e4n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To study whether androgen deprivation therapy (\n                      <jats:styled-content style=\"fixed-case\">ADT<\/jats:styled-content>\n                      ), the mainstay treatment for advanced and disseminated prostate cancer, is associated with risk of dementia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Risk of dementia in men with prostate cancer primarily managed with\n                      <jats:styled-content style=\"fixed-case\">ADT<\/jats:styled-content>\n                      or watchful waiting (\n                      <jats:styled-content style=\"fixed-case\">WW<\/jats:styled-content>\n                      ) in the Prostate Cancer Database Sweden,\n                      <jats:styled-content style=\"fixed-case\">PCB<\/jats:styled-content>\n                      aSe, was compared with that in prostate cancer\u2010free men, matched on birth year and county of residency. We used Cox regression to calculate the hazard ratios (HRs) for Alzheimer's and non\u2010Alzheimer's dementia (vascular dementia, dementia secondary to other diseases or unspecified dementias) for different types and duration of\n                      <jats:styled-content style=\"fixed-case\">ADT<\/jats:styled-content>\n                      and oral antiandrogens (AAs) as well as for men managed with WW.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 25\u00a0967 men with prostate cancer and 121\u00a0018 prostate cancer\u2010free men were followed for a median of 4\u00a0years. In both groups 6% of the men were diagnosed with dementia. In men with prostate cancer, gonadotropin\u2010releasing hormone agonist treatment (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      1.15, 95% confidence interval [\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      ] 1.07\u20131.23) and orchiectomy (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      1.60, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      1.32\u20131.93) were associated with an increased risk of dementia, as compared to no treatment in prostate cancer\u2010free men; however, this increase in risk was only observed for non\u2010Alzheimer's dementia and occurred from year 1\u20134 after start of\n                      <jats:styled-content style=\"fixed-case\">ADT<\/jats:styled-content>\n                      . No increase in risk for any type of dementia was observed for men treated with AAs or for men on\n                      <jats:styled-content style=\"fixed-case\">WW<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This population\u2010based cohort study does not support previous observations of an increased risk of Alzheimer's dementia for men on\n                      <jats:styled-content style=\"fixed-case\">ADT<\/jats:styled-content>\n                      ; however, there was a small increase in risk of non\u2010Alzheimer's dementia.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.14666","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T01:29:13Z","timestamp":1547429353000},"page":"87-92","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Androgen deprivation therapy for prostate cancer and risk of dementia"],"prefix":"10.1111","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3433-8873","authenticated-orcid":false,"given":"David","family":"Robinson","sequence":"first","affiliation":[{"name":"Department of Urology Ryhov Hospital J\u00f6nk\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Garmo","sequence":"additional","affiliation":[{"name":"Regional Cancer Centre Uppsala \u00d6rebro Uppsala University Hospital Uppsala Sweden"},{"name":"School of Cancer and Pharmaceutical Sciences Translational Oncology &amp; Urology Research (TOUR) King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7317-0858","authenticated-orcid":false,"given":"Mieke","family":"Van Hemelrijck","sequence":"additional","affiliation":[{"name":"School of Cancer and Pharmaceutical Sciences Translational Oncology &amp; Urology Research (TOUR) King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan\u2010Erik","family":"Damber","sequence":"additional","affiliation":[{"name":"Department of Urology Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9198-9445","authenticated-orcid":false,"given":"Ola","family":"Bratt","sequence":"additional","affiliation":[{"name":"Department of Urology Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Holmberg","sequence":"additional","affiliation":[{"name":"School of Cancer and Pharmaceutical Sciences Translational Oncology &amp; Urology Research (TOUR) King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars\u2010Olof","family":"Wahlund","sequence":"additional","affiliation":[{"name":"Section\u00a0of Clinical Geriatrics NVS\u2010 Department Karolinska Institutet Karolinska University Hospital Huddinge Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8306-0687","authenticated-orcid":false,"given":"P\u00e4r","family":"Stattin","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Adolfsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Intervention and Technology (CLINTEC) Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.2.7219"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504327"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.62.2.188"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2004.06.019"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e318258cd63"},{"key":"e_1_2_7_7_1","unstructured":"NCCN Guidelines for Prostate Cancer.2016. 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