{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:58:36Z","timestamp":1791986316906,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T00:00:00Z","timestamp":1554249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the oncological and functional outcomes associated with selective tetramodal bladder\u2010sparing therapy, comprising maximal transurethral resection of bladder tumour (TURBT), induction chemoradiotherapy (CRT), and consolidative partial cystectomy (PC) with pelvic lymph node dissection (PLND).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>In the present study, 154 patients with non\u2010metastatic muscle\u2010invasive bladder cancer (MIBC), prospectively enrolled in the tetramodal bladder\u2010preservation protocol, were analysed. After TURBT and induction CRT, patients showing complete remission were offered consolidative PC with PLND for the achievement of bladder preservation. Pathological response to induction CRT was evaluated using PC specimens. Oncological and functional outcomes after bladder preservation were evaluated using the following endpoints: MIBC\u2010recurrence\u2010free survival (RFS); cancer\u2010specific survival (CSS); overall survival (OS), and cross\u2010sectional assessments of preserved bladder function and quality of life (QoL) including uroflowmetry, bladder diary, International Prostate Symptom Score, Overactive Bladder Symptom Score and the 36\u2010item Short\u2010Form Health Survey (SF\u201036) score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median follow\u2010up period was 48 months. Complete MIBC remission was achieved in 121 patients (79%) after CRT, and 107 patients (69%) completed the tetramodal bladder\u2010preservation protocol comprising consolidative PC with PLND. Pathological examination in these 107 patients revealed residual invasive cancer (\u2265pT1) that was surgically removed in 11 patients (10%) and lymph node metastases in two patients (2%). The 5\u2010year MIBC\u2010RFS, CSS and OS rates in the 107 patients who completed the protocol were 97%, 93% and 91%, respectively. As for preserved bladder function, the median maximum voided volume, post\u2010void residual urine volume, and nighttime frequency were 350 mL, 25 mL, and two voids, respectively. In the SF\u201036, patients had favourable scores, equivalent to the age\u2010matched references in all the QoL scales.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Selective tetramodal bladder\u2010preservation therapy, incorporating consolidative PC with PLND, yielded favourable oncological and functional outcomes in patients with MIBC. Consolidative PC may have contributed to the low rate of MIBC recurrence in patients treated according to this protocol.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.14736","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T16:01:40Z","timestamp":1551283300000},"page":"242-250","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Selective tetramodal bladder\u2010preservation therapy, incorporating induction chemoradiotherapy and consolidative partial cystectomy with pelvic lymph node dissection for muscle\u2010invasive bladder cancer: oncological and functional outcomes of 107 patients"],"prefix":"10.1111","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4380-9294","authenticated-orcid":false,"given":"Toshiki","family":"Kijima","sequence":"first","affiliation":[{"name":"Department of Urology Tokyo Medical and Dental University Tokyo 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