{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:43:23Z","timestamp":1791143003298,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T00:00:00Z","timestamp":1557792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000771","name":"Prostate Cancer UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000771","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003122","name":"Ferring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003122","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003083","name":"European Association of Urology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003083","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2019,9]]},"abstract":"\n Objectives<\/jats:title>\n \n To assess the relationship of\n white blood cell count (WBC)<\/jats:styled-content>\n and other routinely collected inflammatory and clinical markers including stone size, stone position, and medical expulsive therapy use (\n MET<\/jats:styled-content>\n ), with spontaneous stone passage (\n SSP<\/jats:styled-content>\n ) in a large contemporary cohort of patients with acute ureteric colic, as there are conflicting data on the role of\n WBC<\/jats:styled-content>\n and other inflammatory markers in SSP in patients with acute ureteric colic.\n <\/jats:p>\n <\/jats:sec>\n \n Patients and methods<\/jats:title>\n \n Multicentre retrospective cohort study coordinated by the British Urology Researchers in Surgical Training (\n BURST<\/jats:styled-content>\n ) Research Collaborative at 71 secondary care hospitals across four countries (UK, Republic of Ireland, Australia, and New Zealand). In all, 4170 patients presented with acute ureteric colic and a computed tomography confirmed single ureteric stone. Our primary outcome measure was\n SSP,<\/jats:styled-content>\n as defined by the absence of need for intervention to assist stone passage (SP). Multivariable mixed effects logistic regression was used to explore the relationship between key patient factors and\n SSP<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In all, 2518 patients were discharged with conservative management and had further follow\u2010up with a\n SSP<\/jats:styled-content>\n rate of 74% (\n n<\/jats:italic>\n \u00a0=\u00a01874\/2518). Sepsis after discharge with conservative management was reported in 0.6% (\n n<\/jats:italic>\n \u00a0=\u00a016\/2518). On multivariable analysis neither\n WBC<\/jats:styled-content>\n , neutrophils count, nor C\u2010reactive protein (\n CRP)<\/jats:styled-content>\n predicted\n SSP<\/jats:styled-content>\n , with an adjusted\n odds ratio (OR)<\/jats:styled-content>\n of 0.97 (95%\n confidence interval [CI]<\/jats:styled-content>\n 0.91\u20131.04,\n P<\/jats:italic>\n \u00a0=\u00a00.38), 1.06 (95%\n CI<\/jats:styled-content>\n 0.99\u20131.13,\n P<\/jats:italic>\n \u00a0=\u00a00.1) and 1.00 (95%\n CI<\/jats:styled-content>\n 0.99\u20131.00,\n P<\/jats:italic>\n \u00a0=\u00a00.17), respectively.\n MET<\/jats:styled-content>\n also did not predict\n SSP<\/jats:styled-content>\n (adjusted\n OR<\/jats:styled-content>\n 1.11, 95%\n CI<\/jats:styled-content>\n 0.76\u20131.61). However, stone size and stone position were significant predictors.\n SSP<\/jats:styled-content>\n for stones <5\u00a0mm was 89% (95%\n CI<\/jats:styled-content>\n 87\u201390) compared to 49% (95%\n CI<\/jats:styled-content>\n 44\u201353) for stones \u22655\u20137\u00a0mm, and 29% (95%\n CI<\/jats:styled-content>\n 23\u201336) for stones >7\u00a0mm. For stones in the upper ureter the\n SSP<\/jats:styled-content>\n rate was 52% (95%\n CI<\/jats:styled-content>\n 48\u201356), middle ureter was 70% (95%\n CI<\/jats:styled-content>\n 64\u201376), and lower ureter was 83% (95%\n CI<\/jats:styled-content>\n 81\u201385).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n In contrast to the previously published literature, we found that in patients with acute ureteric colic who are discharged with initial conservative management neither\n WBC<\/jats:styled-content>\n , neutrophil count, nor\n CRP,<\/jats:styled-content>\n helps determine the likelihood of SSP. We also found no overall benefit from the use of\n MET<\/jats:styled-content>\n . Stone size and position are important predictors and our present findings represent the most comprehensive SP rates for each millimetre increase in stone size from a large contemporary cohort adjusting for key potential confounders. We anticipate that these data will aid clinicians managing patients with acute ureteric colic and help guide management decisions and the need for intervention.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.14777","type":"journal-article","created":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T02:40:35Z","timestamp":1555641635000},"page":"504-513","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Factors associated with spontaneous stone passage in a contemporary cohort of patients presenting with acute ureteric colic: results from the\n Multi\u2010centre cohort study evaluating the role of Inflammatory Markers In patients presenting with acute ureteric Colic (MIMIC)<\/scp>\n study"],"prefix":"10.1111","volume":"124","author":[{"given":"Taimur T.","family":"Shah","sequence":"first","affiliation":[{"name":"British Urology Researchers in Surgical Training (BURST) London UK"},{"name":"Division of Surgery and Cancer Imperial College London London UK"},{"name":"Division of Surgery and Interventional Science University College London London UK"},{"name":"Charing Cross Hospital Imperial Health NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanyu","family":"Gao","sequence":"additional","affiliation":[{"name":"British Urology Researchers in Surgical Training (BURST) London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Cancer Center University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Manning","sequence":"additional","affiliation":[{"name":"Australian Young Urology Researchers Organisation (YURO) Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Cashman","sequence":"additional","affiliation":[{"name":"British Urology Researchers in Surgical Training (BURST) London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun","family":"Nambiar","sequence":"additional","affiliation":[{"name":"British Urology Researchers in Surgical Training (BURST) London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Cumberbatch","sequence":"additional","affiliation":[{"name":"British Urology Researchers in Surgical Training (BURST) London UK"},{"name":"Academic Urology Unit University of Sheffield Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Lamb","sequence":"additional","affiliation":[{"name":"British Urology Researchers in Surgical Training (BURST) London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Peacock","sequence":"additional","affiliation":[{"name":"Information Services Division University College London (UCL) London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke J.","family":"Van Son","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Cancer Center University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter S. 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