{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:11:16Z","timestamp":1790226676992,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T00:00:00Z","timestamp":1559260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To describe incidence and clinical characteristics of bacille Calmette\u2013Gu\u00e9rin (\n                      <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>\n                      ) infections after\n                      <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>\n                      bladder instillation amongst patients with non\u2010muscle\u2010invasive bladder cancer in Denmark.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>\n                      We conducted a nationwide register\u2010based cohort study in Denmark between 2002 through 2017. Patients with\n                      <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>\n                      infection were identified by cross\u2010linking data from the Danish National Hospital Registry on patients treated with\n                      <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>\n                      instillations and patients diagnosed with tuberculosis according to the International Classification of Diseases 10, and data obtained from International Reference Laboratory of Mycobacteriology. Hospital records were reviewed for clinical information.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During the study period, 6753 patients (5281 men; mean [SD] age 71.1\u00a0(0.1)\u00a0years) received\n                      <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>\n                      instillations, of which 66 patients (1%) developed\n                      <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>\n                      infections. There were no differences in age or Charlson Comorbidity Index between the patients in the study population stratified by\n                      <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>\n                      infection. The median (interquartile range) time from first\n                      <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>\n                      instillation until symptoms of\n                      <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>\n                      infection was 169.5\u00a0(38\u2013585)\u00a0days. Extrapulmonary localisation of\n                      <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>\n                      infections (37 patients, 56.1%) was significantly more frequent than pulmonary\n                      <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>\n                      infections (20 patients, 30.3%;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). The most common extrapulmonary localisation was the genitourinary tract (29 patients, 78.4%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>\n                      infections after bladder instillation are rare, mainly affect male patients, and are most frequently extrapulmonary.\n                      <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>\n                      infections should be suspected despite a long time span between occurrence of symptoms and prior bladder instillation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.14793","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T10:13:56Z","timestamp":1557137636000},"page":"910-916","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["The epidemiology of bacille Calmette\u2013Gu\u00e9rin infections after bladder instillation from 2002 through 2017: a nationwide retrospective cohort study"],"prefix":"10.1111","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8459-1682","authenticated-orcid":false,"given":"Emilie S.","family":"Larsen","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Odense University Hospital Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark Odense Denmark"},{"name":"OPEN, Odense Patient data Explorative Network Odense University Hospital\/Institute of Clinical Research University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne C.","family":"Nordholm","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Odense University Hospital Odense Denmark"},{"name":"International Reference Laboratory of Mycobacteriology Statens Serum Institut Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troels","family":"Lillebaek","sequence":"additional","affiliation":[{"name":"International Reference Laboratory of Mycobacteriology Statens Serum Institut Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge K.","family":"Holden","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Odense University Hospital Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isik 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