{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:45:45Z","timestamp":1785890745908,"version":"3.56.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T00:00:00Z","timestamp":1563235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Chong Kun Dang Pharmaceutical Corp., Seoul, Korea"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2019,11]]},"abstract":"\n Objectives<\/jats:title>\n \n To compare the effects of taking tadalafil 5\u00a0mg and placebo once daily on post\u2010micturition dribble (\n PMD<\/jats:styled-content>\n ) in men with lower urinary tract symptoms (\n LUTS<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n Our prospective, randomized, double\u2010blind, placebo\u2010controlled, multicentre trial enrolled 102 men with\n PMD<\/jats:styled-content>\n and other\n LUTS<\/jats:styled-content>\n .\n PMD<\/jats:styled-content>\n was assessed using the Hallym Post\u2010Micturition Dribble Questionnaire (\n HPMDQ<\/jats:styled-content>\n ) and according to\n PMD<\/jats:styled-content>\n volume. Over a 12\u2010week period, patients took either tadalafil 5\u00a0mg (\n n<\/jats:italic>\n = 51) or placebo (\n n<\/jats:italic>\n = 51) once daily and their\n HPMDQ<\/jats:styled-content>\n and\n PMD<\/jats:styled-content>\n volume results were evaluated. Adverse events (\n AE<\/jats:styled-content>\n s) were also reported.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Over the course of 12\u00a0weeks, total\n HPMDQ<\/jats:styled-content>\n scores and\n PMD<\/jats:styled-content>\n volumes improved significantly more in the tadalafil group than in the placebo group (reduction of total\n HPMDQ<\/jats:styled-content>\n score of \u22652 points in the tadalafil and placebo group in 68.8% and 31.9% of patients (\n P<\/jats:italic>\n < 0.001) and decreased mean\n PMD<\/jats:styled-content>\n volume in the tadalafil and placebo group at 0.48\n mL<\/jats:styled-content>\n and 0.22 \u00a0\n mL<\/jats:styled-content>\n , respectively (\n P<\/jats:italic>\n = 0.046). Specifically,\n PMD<\/jats:styled-content>\n frequency decreased and quality of life increased significantly more in the tadalafil group than in the placebo group (\n P<\/jats:italic>\n = 0.029 and\n P<\/jats:italic>\n < 0.001, respectively). Furthermore, 66.7% of the tadalafil group reported moderate and significant\n PMD<\/jats:styled-content>\n improvement, whereas only 4.2% reported that tadalafil was ineffective. Treatment\u2010emergent\n AE<\/jats:styled-content>\n s did not significantly differ between the groups (all\n P<\/jats:italic>\n > 0.05), and no serious\n AE<\/jats:styled-content>\n s were observed.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Taking tadalafil 5\u00a0mg once daily reduced\n PMD<\/jats:styled-content>\n symptom severity and\n PMD<\/jats:styled-content>\n volume in men with\n PMD<\/jats:styled-content>\n , without inducing serious\n AE<\/jats:styled-content>\n s, more effectively than placebo, suggesting that taking tadalafil 5\u00a0mg once daily may be an effective and well\u2010tolerated\n PMD<\/jats:styled-content>\n treatment.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.14849","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T13:11:03Z","timestamp":1560777063000},"page":"862-869","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of tadalafil 5\u00a0mg on post\u2010micturition dribble in men with lower urinary tract symptoms: a multicentre, double\u2010blind, randomized, placebo\u2010controlled trial"],"prefix":"10.1111","volume":"124","author":[{"given":"Dae Yul","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Urology College of Medicine Kangdong Sacred Heart Hospital Hallym Unversity Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Cheol","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Urology College of Medicine Kangdong Sacred Heart Hospital Hallym Unversity Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungtae","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Urology College of Medicine Kangdong Sacred Heart Hospital Hallym Unversity Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Urology College of Medicine Dongtan Sacred Heart Hospital Hallym Unversity Hwaseong Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Kon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Urology College of Medicine Chuncheon Sacred Heart Hospital Hallym Unversity Chuncheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Young","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Urology College of Medicine Chuncheon Sacred Heart Hospital Hallym Unversity Chuncheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0429-191X","authenticated-orcid":false,"given":"Jin Seon","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Urology College of Medicine Hallym University Sacred Heart Hospital Hallym Unversity Anyang 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