{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:58:57Z","timestamp":1790258337848,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T00:00:00Z","timestamp":1563840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2019,11]]},"abstract":"\n Objective<\/jats:title>\n \n To determine the proportion of men avoiding biopsy because of negative multiparametric magnetic resonance imaging (mp\n MRI)<\/jats:styled-content>\n findings in a prostate\n MRI<\/jats:styled-content>\n expert centre, and to assess the number of clinically significant prostate cancers (cs\n PC<\/jats:styled-content>\n a) detected during follow\u2010up.\n <\/jats:p>\n <\/jats:sec>\n \n Patients and methods<\/jats:title>\n \n Retrospective study of 4259 consecutive men having mp\n MRI<\/jats:styled-content>\n of the prostate between January 2012 and December 2017, with either a history of previous negative transrectal ultrasonography\u2010guided biopsy or biopsy na\u00efve. Patients underwent mp\n MRI<\/jats:styled-content>\n in a referral centre. Lesions were classified according to Prostate Imaging Reporting And Data System (\n PI<\/jats:styled-content>\n \u2010\n RADS<\/jats:styled-content>\n ) versions 1 and 2. Negative mp\n MRI<\/jats:styled-content>\n was defined as an index lesion\n PI<\/jats:styled-content>\n \u2010\n RADS<\/jats:styled-content>\n \u22642. Follow\u2010up until 13 October 2018 was collected by searching the Dutch Pathology Registry (\n PALGA<\/jats:styled-content>\n ). Gleason score \u22653 + 4 was considered cs\n PC<\/jats:styled-content>\n a. Kaplan\u2013Meier analysis and univariable logistic regression models were used in the cohort of patients with negative mp\n MRI<\/jats:styled-content>\n and follow\u2010up.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Overall, in 53.6% (2281\/4259) of patients had a lesion classified as PI\u2010RADS \u22642. In 320 patients with\n PI<\/jats:styled-content>\n \u2010\n RADS<\/jats:styled-content>\n 1 or 2, follow\u2010up mp\n MRI<\/jats:styled-content>\n was obtained after a median (interquartile range) of 57 (41\u201363)\u00a0months. In those patients, cs\n PC<\/jats:styled-content>\n a diagnosis\u2010free survival (DFS) was 99.6% after 3\u00a0years. Univariable logistic regression analysis revealed age as a predictor for cs\n PC<\/jats:styled-content>\n a during follow\u2010up (\n P<\/jats:italic>\n \u00a0<\u00a00.05). In biopsied patients, cs\n PC<\/jats:styled-content>\n a was detected in 15.8% (19\/120), 43.2% (228\/528) and 74.5% (483\/648) with\n PI<\/jats:styled-content>\n \u2010\n RADS<\/jats:styled-content>\n 3, 4 and 5, respectively.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n More than half of patients having mp\n MRI<\/jats:styled-content>\n of the prostate avoided biopsy. In those patients, cs\n PC<\/jats:styled-content>\n a DFS was 99.6% after 3\u00a0years.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.14853","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T16:27:35Z","timestamp":1561480055000},"page":"775-784","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Multiparametric magnetic resonance imaging and follow\u2010up to avoid prostate biopsy in 4259 men"],"prefix":"10.1111","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2975-671X","authenticated-orcid":false,"given":"Wulphert","family":"Venderink","sequence":"first","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarijke","family":"van Luijtelaar","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marloes","family":"van der Leest","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelle O.","family":"Barentsz","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sjoerd F.M.","family":"Jenniskens","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiel J.P.","family":"Sedelaar","sequence":"additional","affiliation":[{"name":"Department of Urology Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Hulsbergen\u2010van de Kaa","sequence":"additional","affiliation":[{"name":"Department of Pathology Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiaan G.","family":"Overduin","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurgen J.","family":"F\u00fctterer","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Radboud University Medical Center Nijmegen the 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