{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T06:35:16Z","timestamp":1763015716026,"version":"build-2065373602"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008492","name":"Swiss Continence Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2019,11]]},"abstract":"\n Objectives<\/jats:title>\n \n To investigate whether detrusor overactivity (DO) is missed in a relevant percentage of patients if the urodynamic investigation (\n UDI<\/jats:styled-content>\n ) is stopped at a filling volume of 500\u00a0\n mL<\/jats:styled-content>\n due to the fear of bladder overdistention, in patients with lower urinary tract symptoms and high bladder capacity.\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n A consecutive series of 1598 patients with a bladder capacity of >500\u00a0\n mL<\/jats:styled-content>\n in the bladder diary undergoing\n UDI<\/jats:styled-content>\n due to lower urinary tract dysfunction (LUTD) was prospectively investigated.\n UDI<\/jats:styled-content>\n was performed according to Good Urodynamic Practices recommended by the International Continence Society.\n UDI<\/jats:styled-content>\n was stopped at strong desire to void or in case of autonomic dysreflexia, vesico\u2010uretero\u2010renal reflux, bladder pain or discomfort.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of the 1598 patients (594 women, 1004 men), 1282 (80%) and 316 (20%) had neurogenic and non\u2010neurogenic\n LUTD<\/jats:styled-content>\n , respectively. Overall, DO was detected in 66% (1048\/1598), in 71% (910\/1282) with neurogenic and in 44% (138\/316) with non\u2010neurogenic\n LUTD<\/jats:styled-content>\n . DO occurred in 16% (263\/1598, 95%\n confidence interval [CI]<\/jats:styled-content>\n 14.7\u201318.4%) only at a bladder volume >500\u00a0\n mL<\/jats:styled-content>\n . This phenomenon was significantly (\n P<\/jats:italic>\n \u00a0<\u00a00.001) more frequent in patients with neurogenic (18% [236\/1282], 95%\n CI<\/jats:styled-content>\n 16.4\u201320.6%) compared with non\u2010neurogenic (9% [27\/316], 95%\n CI<\/jats:styled-content>\n 5.9\u201312.1%)\n LUTD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In both neurological and non\u2010neurological patients with high bladder capacity, we strongly recommend not to stop\n UDI<\/jats:styled-content>\n at a bladder volume of 500\u00a0\n mL<\/jats:styled-content>\n , as DO might be missed in a relevant percentage leading to inappropriate patient treatment.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.14868","type":"journal-article","created":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T09:05:29Z","timestamp":1562922329000},"page":"870-875","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Detrusor overactivity is missed by stopping urodynamic investigation at a bladder volume of 500\u00a0\n mL<\/scp>"],"prefix":"10.1111","volume":"124","author":[{"given":"Philipp","family":"Baumeister","sequence":"first","affiliation":[{"name":"Department of Neuro\u2010Urology Balgrist University Hospital University of Z\u00fcrich Z\u00fcrich Switzerland"},{"name":"Department of Urology Cantonal Hospital Luzern Luzern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko","family":"Kozomara","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Urology Balgrist University Hospital University of Z\u00fcrich Z\u00fcrich 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