{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T01:39:54Z","timestamp":1774661994790,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T00:00:00Z","timestamp":1566777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"\n Objective<\/jats:title>\n \n To evaluate the prognostic impact of lymph node yield (\n LNY<\/jats:styled-content>\n ) on survival outcomes for penile squamous cell carcinoma (SCC).\n <\/jats:p>\n <\/jats:sec>\n \n Patients and methods<\/jats:title>\n \n In all, 532 patients who underwent inguinal LN dissection (\n ILND<\/jats:styled-content>\n ) across tertiary referral centres from Europe, China, Brazil and North America were retrospectively evaluated. From this cohort, 198 patients received pelvic LND (\n PLND<\/jats:styled-content>\n ).We identified threshold values for\n ILND<\/jats:styled-content>\n and\n PLND<\/jats:styled-content>\n using receiver operating characteristic curves. We tested prognostic value of\n LNY<\/jats:styled-content>\n for recurrence\u2010free survival (\n RFS<\/jats:styled-content>\n ), disease\u2010specific survival (\n DSS<\/jats:styled-content>\n ), and overall survival (\n OS<\/jats:styled-content>\n ) using the Kaplan\u2013Meir method and Cox proportional hazard regression models.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The median (interquartile [IQR]) age was 59\u00a0(49\u201368)\u00a0years and the median (IQR) follow\u2010up after\n ILND<\/jats:styled-content>\n was 28\u00a0(12\u201368.2)\u00a0months. Overall, 85% of the patients had bilateral dissections. The median (IQR) number of inguinal\n LN<\/jats:styled-content>\n s removed was 15\u00a0(10\u201322). Of those receiving\n PLND<\/jats:styled-content>\n , The median (IQR) number of\n LN<\/jats:styled-content>\n s was 13\u00a0(8\u201319).\n A LNY<\/jats:styled-content>\n of \u226515 was used for dichotomisation of\n ILND<\/jats:styled-content>\n patients, and\n a LNY<\/jats:styled-content>\n of \u22659 was used in the\n PLND<\/jats:styled-content>\n cohort. Patients with a\n LNY<\/jats:styled-content>\n \u226515 had significantly better 5\u2010year\n OS<\/jats:styled-content>\n vs patients with\n a LNY<\/jats:styled-content>\n <15 (70.1% vs 58.7%). On multivariable analyses, a\n LNY<\/jats:styled-content>\n \u226515 was a predictor of\n OS<\/jats:styled-content>\n (\n hazard ratio [HR]<\/jats:styled-content>\n 0.68,\n P\u00a0<\/jats:italic>\n =\u00a00.029). For\n cN<\/jats:styled-content>\n 0 patients,\n a LNY<\/jats:styled-content>\n \u226515 was an independent predictor of\n RFS<\/jats:styled-content>\n (\n HR<\/jats:styled-content>\n 0.52,\n P<\/jats:italic>\n \u00a0=\u00a00.043) and\n OS<\/jats:styled-content>\n (\n HR<\/jats:styled-content>\n 0.53,\n P<\/jats:italic>\n \u00a0=\u00a00.021). In the\n PLND<\/jats:styled-content>\n cohort,\n a LNY<\/jats:styled-content>\n \u22659 was a predictor of\n RFS<\/jats:styled-content>\n (\n HR<\/jats:styled-content>\n 0.53,\n P<\/jats:italic>\n \u00a0=\u00a00.032).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Using one of the largest LND datasets to date, we found\n LNY<\/jats:styled-content>\n to be a significant predictor of outcomes after lymphatic staging for penile\n SCC<\/jats:styled-content>\n . Prospective validation is warranted.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.14883","type":"journal-article","created":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T12:53:27Z","timestamp":1564404807000},"page":"82-88","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Identifying an optimal lymph node yield for penile squamous cell carcinoma: prognostic impact of surgical dissection"],"prefix":"10.1111","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2603-0382","authenticated-orcid":false,"given":"Juan","family":"Chipollini","sequence":"first","affiliation":[{"name":"The University of Arizona College of Medicine Tucson AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2705-7843","authenticated-orcid":false,"given":"Mounsif","family":"Azizi","sequence":"additional","affiliation":[{"name":"H. 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