{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:44:27Z","timestamp":1761745467158,"version":"build-2065373602"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T00:00:00Z","timestamp":1569542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001593","name":"Irish Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1K24CA160653"],"award-info":[{"award-number":["1K24CA160653"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2020,2]]},"abstract":"\n Objective<\/jats:title>\n \n To test the association between statin use and prostate volume (\n PV<\/jats:styled-content>\n ) change over time using data from the REduction by DUtasteride of prostate Cancer Events\n (REDUCE) trial<\/jats:styled-content>\n , a 4\u2010year randomised controlled trial testing dutasteride for prostate cancer chemoprevention.\n <\/jats:p>\n <\/jats:sec>\n \n Subjects\/Patients and Methods<\/jats:title>\n \n We identified men with a baseline negative prostate biopsy from\n REDUCE<\/jats:styled-content>\n who did not undergo prostate surgery or develop prostate cancer over the trial period. Men reported statin use at baseline.\n PV<\/jats:styled-content>\n was determined from transrectal ultrasonography performed to guide prostate biopsy at baseline, and 2\u2010 and 4\u2010years after randomisation. Multivariable generalised estimating equations tested differences in\n PV<\/jats:styled-content>\n change over time by statin use, overall and stratified by treatment arm. We tested for interactions between statins and time in association with\n PV<\/jats:styled-content>\n using the Wald test.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 4106 men, 17% used statins at baseline. Baseline\n PV<\/jats:styled-content>\n did not differ by statin use. Relative to non\u2010users, statin users had decreasing\n PV<\/jats:styled-content>\n s over the trial period (\n P\u00a0<\/jats:italic>\n =\u00a00.027). Similar patterns were seen in the dutasteride and placebo arms, although neither reached statistical significance. The mean estimated\n PV<\/jats:styled-content>\n was modestly but significantly lower in statin users relative to non\u2010users in the dutasteride arm at 2\u2010years (4.5%,\n P<\/jats:italic>\n \u00a0=\u00a00.032) and 4\u2010years (4.0%,\n P<\/jats:italic>\n \u00a0=\u00a00.033), with similar (3\u20133.3%) but non\u2010significant effects in the placebo arm.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n If confirmed, our present findings support a role for statins in modestly attenuating\n PV<\/jats:styled-content>\n growth, with a magnitude of effect in line with previously reported prostate\u2010specific antigen\u2010lowering effects of statins (~4%). Future studies are needed to assess whether this putative role for statins in\n PV<\/jats:styled-content>\n growth could impact lower urinary tract symptom development or progression.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.14905","type":"journal-article","created":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T15:55:00Z","timestamp":1567526100000},"page":"226-233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Statin use and longitudinal changes in prostate volume; results from the REduction by DUtasteride of prostate Cancer Events (\n REDUCE)<\/scp>\n trial"],"prefix":"10.1111","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1227-3615","authenticated-orcid":false,"given":"Emma H.","family":"Allott","sequence":"first","affiliation":[{"name":"Centre for Cancer Research and Cell Biology Queen's University Belfast Belfast UK"},{"name":"Department of Histopathology and Morbid Anatomy Trinity Translational Medicine Institute Trinity College Dublin Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilona","family":"Csizmadi","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Urology Cedars\u2010Sinai Medical Center Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren E.","family":"Howard","sequence":"additional","affiliation":[{"name":"Duke Cancer Institute Duke University School of Medicine Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto L.","family":"Muller","sequence":"additional","affiliation":[{"name":"Division of Urology Center of Oncologic Research (CEPON) Florianopolis Santa Catarina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel M.","family":"Moreira","sequence":"additional","affiliation":[{"name":"Department of Urology University of Illinois at Chicago Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald L.","family":"Andriole","sequence":"additional","affiliation":[{"name":"Division of Urologic Surgery Department of Surgery Washington University School of Medicine St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus G.","family":"Roehrborn","sequence":"additional","affiliation":[{"name":"Department of Urology UT Southwestern Medical Center Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8104-6419","authenticated-orcid":false,"given":"Stephen J.","family":"Freedland","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Urology Cedars\u2010Sinai Medical Center Los Angeles CA USA"},{"name":"Urology Section Veterans Affairs Medical Center Durham NC 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