{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T14:53:10Z","timestamp":1761749590355,"version":"build-2065373602"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T00:00:00Z","timestamp":1577318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Partly funded by a Psychology Fellowship from the Dutch Cancer Society granted to Dounya Schoormans","award":["UvT2013-5893"],"award-info":[{"award-number":["UvT2013-5893"]}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the associations between pharmaceutically treated anxiety and depression and incident cardiovascular disease (CVD) among 1\u2010year prostate cancer survivors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>A registry\u2010based cohort study design was used to describe the risk of incident CVD in adult 1\u2010year prostate cancer survivors without a history of CVD. Patients with prostate cancer diagnosed between 1999 and 2011 were selected from the Netherlands Cancer Registry. Drug dispenses were retrieved from the PHARMO Database Network and were used as proxy for CVD, anxiety, and depression. Data were analysed using Cox regression analysis to examine the risk associations between pharmaceutically treated anxiety and depression entered as a time\u2010varying predictor with incident CVD in 1\u2010year prostate cancer survivors, while controlling for age, traditional CVD risk factors, and clinical characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 5262 prostate cancer survivors, 327 (6%) developed CVD during the 13\u2010year follow\u2010up period. Prostate cancer survivors who were pharmaceutically treated for depression had an increased risk of incident CVD after full adjustment compared to prostate cancer survivors who were not pharmaceutically treated for depression (hazard ratio [HR] 1.51, 95% confidence interval [CI] 1.06\u20132.15). The increased risk of incident CVD amongst those pharmaceutically treated for depression compared to those who were not pharmaceutically treated for depression, was only valid among: prostate cancer survivors who were aged \u226465\u00a0years (HR 2.91; 95% CI 1.52\u20135.55); those who were not treated with radiotherapy (HR 1.63; 95% CI 1.01\u20132.65); those who were treated with hormones (HR 1.76; 95% CI 1.09\u20132.85); those who were not operated upon (HR 1.55; 95% CI 1.07\u20132.25); and those with tumour stage III (HR 2.21; 95% CI 1.03\u20134.74) and stage IV (HR 2.47; 95% CI 1.03\u20135.89).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with prostate cancer who were pharmaceutically treated for depression had a 51% increased risk of incident CVD after adjustment for anxiety, age, traditional CVD risk factors, and clinical characteristics. The results emphasise the need to pay attention to (pharmaceutically treated) depressed patients with prostate cancer prior to deciding on prostate cancer treatment and for a timely detection and treatment of CVD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.14961","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T02:06:19Z","timestamp":1574820379000},"page":"433-441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The risk of developing cardiovascular disease is increased for patients with prostate cancer who are pharmaceutically treated for depression"],"prefix":"10.1111","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5145-9618","authenticated-orcid":false,"given":"Barbara M.","family":"Wollersheim","sequence":"first","affiliation":[{"name":"Division of Psychosocial Research and Epidemiology The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3637-0655","authenticated-orcid":false,"given":"Annelies H.","family":"Boekhout","sequence":"additional","affiliation":[{"name":"Division of Psychosocial Research and Epidemiology The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8772-1120","authenticated-orcid":false,"given":"Henk G.","family":"van der Poel","sequence":"additional","affiliation":[{"name":"Department of Urology The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0413-6872","authenticated-orcid":false,"given":"Lonneke V.","family":"van de Poll\u2010Franse","sequence":"additional","affiliation":[{"name":"Division of Psychosocial Research and Epidemiology The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital Amsterdam The Netherlands"},{"name":"Department of Research Netherlands Comprehensive Cancer organization (IKNL) Utrecht The Netherlands"},{"name":"Department of Medical and Clinical Psychology CoRPS \u2013 Center of Research on Psychology in Somatic Diseases Tilburg University Tilburg The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4476-2747","authenticated-orcid":false,"given":"Dounya","family":"Schoormans","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Psychology CoRPS \u2013 Center of Research on Psychology in Somatic Diseases Tilburg University Tilburg The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21234"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860701367878"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1754"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-018-1202-x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S16747"},{"volume-title":"Prevention of Cardiovascular Disease: Guideline for Assessment and Management of Total Cardiovascular Risk","year":"2007","author":"World Health Organization","key":"e_1_2_7_7_1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs092"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.020406"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.64.0409"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.03.034"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.06.055"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.psy.0000162253.07959.db"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1723"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-003901"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.03.025"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40959-016-0019-x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-017-4387-1"},{"key":"e_1_2_7_19_1","unstructured":"Janssen\u2010HeijnenML LouwmannWJ Van de Poll\u2010FranseLV CoeberghJW.Results of 50 years cancer registry in the South of the Netherlands: 1955\u20132004 (in Dutch) 2005"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.09.010"},{"key":"e_1_2_7_21_1","unstructured":"WHO Collaborating Centre for Drug Statistics Methodology.Guidelines for ATC classification and DDD assignment. 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