{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T21:07:00Z","timestamp":1787692020659,"version":"build-2784847793"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T00:00:00Z","timestamp":1580342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Janssen Medical Affairs Asia Pacific"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2020,4]]},"abstract":"\n Objectives<\/jats:title>\n To document the management of advanced prostate cancer including diagnosis, prognosis, treatment, and care, in real\u2010world practice in Asia using the United in Fight against prOstate cancer (UFO) registry.<\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n We established a multi\u2010national, longitudinal, observational registry of patients with prostate cancer presenting to participating tertiary care hospitals in eight Asian countries. A total of 3636 eligible patients with existing or newly diagnosed high\u2010risk localised prostate cancer (HRL), non\u2010metastatic biochemically recurrent prostate cancer (M0), or metastatic prostate cancer (M1), were consecutively enrolled and are being followed\u2010up for 5\u00a0years. Patient history, demographic and disease characteristics, treatment and treatment decisions, were collected at first prostate cancer diagnosis and at enrolment. Patient\u2010reported quality of life was prospectively assessed using the European Quality of Life\u2010five Dimensions, five Levels (EQ\u20105D\u20105L) and Functional Assessment of Cancer Therapy for Prostate Cancer questionnaires. In the present study, we report the first interim analysis of 2063 patients enrolled from study start (15 September 2015) until 18 May 2017.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Of the 2063 enrolled patients, 357 (17%), 378 (19%), and 1328 (64%) had HRL, M0 or M1 prostate cancer, respectively. The mean age at first diagnosis was similar in each group, 56% of all patients had extracapsular extension of their tumour, 28% had regional lymph node metastasis, and 53% had distant metastases. At enrolment, 62% of patients had at least one co\u2010morbidity (mainly cardiovascular disease or diabetes), 91.8% of M1 patients had an Eastern Cooperative Oncology Group performance score of <2 and the mean EQ\u20105D\u20105L visual analogue score was 74.6\u201379.6 across cohorts. Treatment of M1 patients was primarily with combined androgen blockade (58%) or androgen\u2010deprivation therapy (either orchidectomy or luteinising hormone\u2010releasing hormone analogues) (32%). Decisions to start therapy were mainly driven by treatment guidelines and disease progression. Decision to discontinue therapy was most often due to disease progression (hormonal drug therapy) or completion of therapy (chemotherapy).<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n In the UFO registry of advanced prostate cancer in Asia, regional differences exist in prostate cancer treatment patterns that will be explored more deeply during the follow\u2010up period; prospective follow\u2010up is ongoing. The UFO registry will provide valuable descriptive data on current disease characteristics and treatment landscape amongst patients with prostate cancer in Asia.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.14980","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T09:15:26Z","timestamp":1577092526000},"page":"541-552","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["United in Fight against prOstate cancer (UFO) registry: first results from a large, multi\u2010centre, prospective, longitudinal cohort study of advanced prostate cancer in Asia"],"prefix":"10.1111","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3665-9523","authenticated-orcid":false,"given":"Hirotsugu","family":"Uemura","sequence":"first","affiliation":[{"name":"Department of Urology Kindai University Faculty of Medicine Osaka\u2010Sayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingwei","family":"Ye","sequence":"additional","affiliation":[{"name":"Fudan University Shanghai Cancer Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindran","family":"Kanesvaran","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology National Cancer Centre Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmund","family":"Chiong","sequence":"additional","affiliation":[{"name":"Department of Urology National University Hospital National University Health System Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bannakij","family":"Lojanapiwat","sequence":"additional","affiliation":[{"name":"Division of Urology Faculty of Medicine Chiang Mai University Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeong\u2010Shiau","family":"Pu","sequence":"additional","affiliation":[{"name":"Department of Urology National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhir Kumar","family":"Rawal","sequence":"additional","affiliation":[{"name":"Rajeev Gandhi Cancer Institute New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azad Hassan","family":"Abdul Razack","sequence":"additional","affiliation":[{"name":"Department of Surgery Faculty of Medicine University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Urology West China Hospital Sichuan University Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9817-3660","authenticated-orcid":false,"given":"Byung Ha","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Urology and Urological Science Institute Gangnam Severance Hospital Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor Ashani","family":"Md Yusoff","sequence":"additional","affiliation":[{"name":"Urology Department Institute Urology and Nephrology Hospital Kuala Lumpur Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikara","family":"Ohyama","sequence":"additional","affiliation":[{"name":"Department of Urology Hirosaki University Graduate School of Medicine Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7464-3207","authenticated-orcid":false,"given":"Choung Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Asan Medical Center University of Ulsan College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunai","family":"Leewansangtong","sequence":"additional","affiliation":[{"name":"Division of Urology Department of Surgery Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuh\u2010Shyan","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Urology College of Medicine National Cheng Kung University Hospital National Cheng Kung University Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Global Epidemiology Johnson & Johnson New Brunswick NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Liu","sequence":"additional","affiliation":[{"name":"Janssen Research and Development Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximiliano","family":"van Kooten Losio","sequence":"additional","affiliation":[{"name":"Janssen Medical Affairs, Asia Pacific Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marxengel","family":"Asinas\u2010Tan","sequence":"additional","affiliation":[{"name":"Janssen Medical Affairs, Asia Pacific Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/1008-682X.132780"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.13593"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.12954\/PI.12014"},{"key":"e_1_2_11_5_1","first-page":"83","article-title":"Rising incidence of prostate cancer in Shanghai, China","volume":"7","author":"Hsing AW","year":"1998","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyt038"},{"key":"e_1_2_11_7_1","first-page":"3","article-title":"Singapore cancer trends in the last decade","volume":"53","author":"Lim GH","year":"2012","journal-title":"Singapore Med J"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2014.42"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prnil.2018.12.001"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8510(90)90421-9"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(97)00459-7"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajur.2014.08.007"},{"key":"e_1_2_11_13_1","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1097\/01.inf.0000145427.19167.35","article-title":"Immunogenicity and reactogenicity of a three\u2010dose primary vaccination course with a combined diphtheria\u2010tetanus\u2010acellular pertussis\u2010hepatitis B\u2010inactivated polio\u2010haemophilus influenzae type b vaccine coadministered with a meningococcal C conjugate vaccine","volume":"23","author":"Tejedor JC","year":"2004","journal-title":"Pediatr Infect Dis J"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1322"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13104"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prnil.2018.06.001"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyz053"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4166-3"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbju.14980","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.14980","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bju.14980","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.14980","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T11:27:36Z","timestamp":1761737256000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.14980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,30]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1111\/bju.14980"],"URL":"https:\/\/doi.org\/10.1111\/bju.14980","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,30]]},"assertion":[{"value":"2020-01-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}