{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:25:38Z","timestamp":1789647938525,"version":"4.0.0"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,19]],"date-time":"2020-01-19T00:00:00Z","timestamp":1579392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Hospital Italiano de Buenos Aires"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the effects of pharmacological therapies for chronic prostatitis\/chronic pelvic pain syndrome (CP\/CPPS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>We performed a comprehensive search using multiple databases, trial registries, grey literature and conference proceedings with no restrictions on the language of publication or publication status. The date of the latest search of all databases was July 2019. We included randomised controlled trials. Inclusion criteria were men with a diagnosis of CP\/CPPS. We included all available pharmacological interventions. Two review authors independently classified studies and abstracted data from the included studies, performed statistical analyses and rated quality of evidence according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methods. The primary outcomes were prostatitis symptoms and adverse events. The secondary outcomes were sexual dysfunction, urinary symptoms, quality of life, anxiety and depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 99 unique studies in 9119 men with CP\/CPPS, with assessments of 16 types of pharmacological interventions. Most of our comparisons included short\u2010term follow\u2010up information. The median age of the participants was 38\u00a0years. Most studies did not specify their funding sources; 21 studies reported funding from pharmaceutical companies.<\/jats:p>\n                    <jats:p>We found low\u2010 to very low\u2010quality evidence that \u03b1\u2010blockers may reduce prostatitis symptoms based on a reduction in National Institutes of Health \u2013 Chronic Prostatitis Symptom Index (NIH\u2010CPSI) scores of &gt;2 (but &lt;8) with an increased incidence of minor adverse events such as dizziness and hypotension. Moderate\u2010 to low\u2010quality evidence indicates that 5\u03b1\u2010reductase inhibitors, antibiotics, anti\u2010inflammatories, and phytotherapy probably cause a small decrease in prostatitis symptoms and may not be associated with a greater incidence of adverse events. Intraprostatic botulinum toxin A (BTA) injection may cause a large reduction in prostatitis symptoms with procedure\u2010related adverse events (haematuria), but pelvic floor muscle BTA injection may not have the same effects (low\u2010quality evidence). Allopurinol may also be ineffective for reducing prostatitis symptoms (low\u2010quality evidence). We assessed a wide range of interventions involving traditional Chinese medicine; low\u2010quality evidence showed they may reduce prostatitis symptoms without an increased incidence in adverse events.<\/jats:p>\n                    <jats:p>\n                      Moderate\u2010 to high\u2010quality evidence indicates that the following interventions may be ineffective for the reduction of prostatitis symptoms: anticholinergics,\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                      lysate (OM\u201089), pentosan, and pregabalin. Low\u2010 to very low\u2010quality evidence indicates that antidepressants and tanezumab may be ineffective for the reduction of prostatitis symptoms. Low\u2010quality evidence indicates that mepartricin and phosphodiesterase inhibitors may reduce prostatitis symptoms, without an increased incidence in adverse events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Based on the findings of low\u2010 to very low\u2010quality evidence, this review found that some pharmacological interventions such as \u03b1\u2010blockers may reduce prostatitis symptoms with an increased incidence of minor adverse events such as dizziness and hypotension. Other interventions may cause a reduction in prostatitis symptoms without an increased incidence of adverse events while others were found to be ineffective.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.14988","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T12:38:06Z","timestamp":1578055086000},"page":"490-496","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Pharmacological interventions for treating chronic prostatitis\/chronic pelvic pain syndrome: a Cochrane systematic review"],"prefix":"10.1111","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0411-899X","authenticated-orcid":false,"given":"Juan V.A.","family":"Franco","sequence":"first","affiliation":[{"name":"Argentine Cochrane Centre Instituto Universitario Hospital Italiano Buenos Aires 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Ignacio","family":"Tirapegui","sequence":"additional","affiliation":[{"name":"Urology Division Hospital Italiano de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Garrote","sequence":"additional","affiliation":[{"name":"Biblioteca Central Instituto Universitario Hospital Italiano Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Vietto","sequence":"additional","affiliation":[{"name":"Family and Community Medicine Service Hospital Italiano de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,19]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"571","article-title":"Prostatitis: prevalence, health impact and quality improvement strategies","volume":"69","author":"Bajpayee P","year":"2012","journal-title":"Acta Pol 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