{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T04:49:34Z","timestamp":1771649374992,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T00:00:00Z","timestamp":1584662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK107450"],"award-info":[{"award-number":["R01 DK107450"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To report the effect of a selective androgen receptor modulators (SARMs) on the urethral continence mechanisms in a rat model of stress urinary incontinence (SUI) induced by bilateral ovariectomy (OVX).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      Female Sprague\u2010Dawley rats with bilateral OVX were used. Rats were divided into five groups; sham operated, vehicle\u2010treated OVX, low\u2010dose SARM\u2010treated OVX (GSK2849466A: 0.005\u00a0mg\/kg\/day,\n                      <jats:italic>per os<\/jats:italic>\n                      [p.o.]), high\u2010dose SARM\u2010treated OVX (GSK2849466A: 0.03\u00a0mg\/kg\/day, p.o.) and dihydrotestosterone (DHT)\u2010treated OVX (1\u00a0mg\/kg\/day, subcutaneous) groups. After 4\u00a0weeks of SARM treatments or 3\u00a0weeks of DHT treatment (6\u00a0weeks after OVX), rats were subjected to evaluation of the sneeze\u2010induced continence reflex using microtransducer\u2010tipped catheter methods, sneeze\u2010induced leak\u2010point pressure, and continuous cystometry measurements, followed by histological analyses of urethral tissues.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>(i) OVX significantly impaired urethral continence function after 6\u00a0weeks to induce SUI during sneezing. (ii) Low\u2010dose SARM treatment restored urethral baseline pressure (UBP) without affecting the amplitude of urethral response during sneezing (A\u2010URS), partially reversing OVX\u2010induced SUI during sneezing. (iii) High\u2010dose SARM treatment reversed decreases in both UBP and A\u2010URS, more effectively preventing SUI during sneezing. (iv) DHT treatment only restored A\u2010URS without affecting UBP, partially preventing OVX\u2010induced SUI during sneezing. (v) The high\u2010dose SARM treatment induced hypertrophy of the striated and smooth muscle around the urethra. (vi) SARM treatment did not affect bladder function in sham or OVX rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Treatment with SARMs could be a more effective modality for the treatment of SUI than DHT, without affecting bladder function, by enhancing smooth\u2010 and striated muscle\u2010mediated urethral function under stress conditions such as sneezing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15022","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T07:19:45Z","timestamp":1580714385000},"page":"911-919","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effects of a selective androgen receptor modulator (SARM), GSK2849466A, on stress urinary incontinence and bladder activity in rats with ovariectomy\u2010induced oestrogen deficiency"],"prefix":"10.1111","volume":"125","author":[{"given":"Katsumi","family":"Kadekawa","sequence":"first","affiliation":[{"name":"Department of Urology University of Pittsburgh Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Kawamorita","sequence":"additional","affiliation":[{"name":"Department of Urology University of Pittsburgh Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Urology University of Pittsburgh Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Kurobe","sequence":"additional","affiliation":[{"name":"Department of Urology University of Pittsburgh Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip S.","family":"Turnbull","sequence":"additional","affiliation":[{"name":"Muscle Metabolism DPU GlaxoSmithKline King of Prussia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sundeep","family":"Chandra","sequence":"additional","affiliation":[{"name":"Muscle Metabolism DPU GlaxoSmithKline King of Prussia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahito","family":"Kambara","sequence":"additional","affiliation":[{"name":"Pathology, Translational Medicine &amp; 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