{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T09:19:36Z","timestamp":1768900776657,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T00:00:00Z","timestamp":1582761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the perioperative outcomes of holmium laser enucleation of the prostate (HoLEP) in real\u2010life practice and investigate the factors influencing the safety and effectiveness of the technique.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      Critical analysis of patients with benign prostate hyperplasia (BPH) treated with HoLEP over 10\u00a0years of routine practice in three hospitals. Analysed variables included: preoperative characteristics (prostate size, active antiplatelet\/anticoagulant therapy, blood parameters. prostate\u2010specific antigen (PSA) level, maximum urinary flow rate [Q\n                      <jats:sub>max<\/jats:sub>\n                      ], and International Prostate Symptom Score [IPSS]), intraoperative variables (operation time, concomitant removal of bladder calculi, and complications), early postoperative outcomes (change in blood parameters, catheterisation time, and hospital stay), and 12\u2010month follow\u2010up outcomes (change in IPSS, PSA level, and Q\n                      <jats:sub>max<\/jats:sub>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The analysis included 963 patients, aged 48\u201391\u00a0years, with a mean (range) prostate size of 91\u00a0(35\u2013247)\u00a0mL. The mean (\n                      <jats:sc>sd<\/jats:sc>\n                      ) operation time was 77\u00a0(29)\u00a0min, and the hospital stay and catheterisation time were 4\u00a0(2) and 1.3\u00a0(2)\u00a0days, respectively. In all, 56 patients (5.6%) required concomitant removal of bladder calculi and 36 (3.7%) were converted to open prostatectomy or transurethral resection of the prostate due to intraoperative complications. Patients had a significant decrease in haemoglobin and haematocrit, but no differences were seen between patients with and without anticoagulant\/antiplatelet therapy and those with prostates \u2265 and &lt;100\u00a0mL. The concomitant removal of bladder calculi and having a prostate \u2265100\u00a0mL resulted in a longer operation time, but did not influence the safety and effectiveness outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HoLEP is suitable for real\u2010life patients with BPH, irrespective of the presence of active treatment with anticoagulant\/antiplatelet, bladder lithiasis or a prostate \u2265100\u00a0mL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15028","type":"journal-article","created":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T03:56:30Z","timestamp":1580874990000},"page":"177-182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Critical analysis of a multicentric experience with holmium laser enucleation of the prostate for benign prostatic hyperplasia: outcomes and complications of 10\u00a0years of routine clinical practice"],"prefix":"10.1111","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0666-5105","authenticated-orcid":false,"given":"Javier","family":"Romero\u2010Otero","sequence":"first","affiliation":[{"name":"Urology Department, Grupo de Investigaci\u00f3n Salud Integral del Var\u00f3n imas12 Hospital Universitario 12 Octubre Madrid Spain"},{"name":"Hospital Universitario HM Montepr\u00edncipe Madrid Spain"},{"name":"Hospital Universitario La Luz Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1071-3656","authenticated-orcid":false,"given":"Borja","family":"Garc\u00eda\u2010G\u00f3mez","sequence":"additional","affiliation":[{"name":"Urology Department, Grupo de Investigaci\u00f3n Salud Integral del Var\u00f3n imas12 Hospital Universitario 12 Octubre Madrid Spain"},{"name":"Hospital Universitario HM Montepr\u00edncipe Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc\u00eda","family":"Garc\u00eda\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Urology Department, Grupo de Investigaci\u00f3n Salud Integral del Var\u00f3n imas12 Hospital Universitario 12 Octubre Madrid Spain"},{"name":"Hospital Universitario La Luz Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Garc\u00eda\u2010Rojo","sequence":"additional","affiliation":[{"name":"Urology Department, Grupo de Investigaci\u00f3n Salud Integral del Var\u00f3n imas12 Hospital Universitario 12 Octubre Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Abad\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Urology Department, Grupo de Investigaci\u00f3n Salud Integral del Var\u00f3n imas12 Hospital Universitario 12 Octubre Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Justo\u2010Quintas","sequence":"additional","affiliation":[{"name":"Hospital Universitario HM Montepr\u00edncipe Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Duarte\u2010Ojeda","sequence":"additional","affiliation":[{"name":"Urology Department, Grupo de Investigaci\u00f3n Salud Integral del Var\u00f3n imas12 Hospital Universitario 12 Octubre Madrid Spain"},{"name":"Hospital Universitario La Luz Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Rodr\u00edguez\u2010Antol\u00edn","sequence":"additional","affiliation":[{"name":"Urology Department, Grupo de Investigaci\u00f3n Salud Integral del Var\u00f3n imas12 Hospital Universitario 12 Octubre Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.31"},{"key":"e_1_2_8_3_1","first-page":"S3","article-title":"Benign prostatic hyperplasia: an overview","volume":"7","author":"Roehrborn CG","year":"2005","journal-title":"Rev Urol"},{"key":"e_1_2_8_4_1","first-page":"S90","article-title":"The cost of treating the 10 most prevalent diseases in men 50 years of age or older","volume":"4","author":"Fenter TC","year":"2006","journal-title":"Am J Manag Care"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eursup.2006.02.005"},{"key":"e_1_2_8_6_1","article-title":"Management of Non\u2010Neurogenic Male Lower Urinary Tract Symptoms (LUTS), incl. 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