{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T11:56:04Z","timestamp":1781870164055,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T00:00:00Z","timestamp":1589414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Research, Development and Innovation Office","award":["NKFIH\/FK 12443"],"award-info":[{"award-number":["NKFIH\/FK 12443"]}]},{"name":"National Research, Development and Innovation Office","award":["NVKP_16-1-2016-004"],"award-info":[{"award-number":["NVKP_16-1-2016-004"]}]},{"name":"J\u00e1nos Bolyai Research Scholarship of the Hungarian Academy of Sciences"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess chromogranin A (CGA) and neuron\u2010specific enolase (NSE) levels and changes in these at different stages of prostatic adenocarcinoma (PCA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Overall, 1095 serum samples from 395 patients, divided into three treatment groups, were analysed; the radical prostatectomy (RP) cohort (\n                      <jats:italic>n<\/jats:italic>\n                      = 157) included patients with clinically localized PCA, while the docetaxel (DOC) and the abiraterone (ABI)\/enzalutamide (ENZA) cohorts included 95 and 143 patients, respectively, with metastatic castration\u2010resistant prostate cancer. CGA, NSE and total PSA levels were measured using the KRYPTOR method.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline CGA and NSE levels were higher in castration\u2010resistant (DOC and ABI\/ENZA cohorts) than in hormone\u2010na\u00efve, clinically localized PCA (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001). High baseline CGA levels were independently associated with poor overall survival in both the DOC and the ABI\/ENZA cohorts, with a stronger association in the ABI\/ENZA cohort. In the ABI\/ENZA cohort, a &gt; 50% CGA increase at 3\u00a0months was associated with poor survival, especially in patients with high baseline CGA levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The two\u2010 to threefold higher neuroendocrine marker levels in castration\u2010resistant compared to hormone\u2010na\u00efve PCA support the presence of neuroendocrine transdifferentiation under androgen deprivation therapy. Our results showed patients with high baseline CGA levels who experienced a further CGA increase during ABI and ENZA treatment had the poorest prognosis. Serum CGA levels could help in tailoring and monitoring therapy in advanced PCA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15086","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T22:05:53Z","timestamp":1587420353000},"page":"44-55","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Comprehensive analysis of serum chromogranin A and neuron\u2010specific enolase levels in localized and castration\u2010resistant prostate cancer"],"prefix":"10.1111","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6321-0799","authenticated-orcid":false,"given":"Tibor","family":"Szarvas","sequence":"first","affiliation":[{"name":"Department of Urology Semmelweis University Budapest Hungary"},{"name":"Department of Urology Faculty of Medicine University Duisburg\u2010Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8394-3722","authenticated-orcid":false,"given":"Anita","family":"Csizmarik","sequence":"additional","affiliation":[{"name":"Department of Urology Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Fazekas","sequence":"additional","affiliation":[{"name":"Department of Urology Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e1s","family":"H\u00fcttl","sequence":"additional","affiliation":[{"name":"Department of Urology Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Nyir\u00e1dy","sequence":"additional","affiliation":[{"name":"Department of Urology Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Hadaschik","sequence":"additional","affiliation":[{"name":"Department of Urology Faculty of Medicine University Duisburg\u2010Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor","family":"Gr\u00fcnwald","sequence":"additional","affiliation":[{"name":"Department of Urology Faculty of Medicine University Duisburg\u2010Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7505-1740","authenticated-orcid":false,"given":"Lukas","family":"P\u00fcllen","sequence":"additional","affiliation":[{"name":"Department of Urology Faculty of Medicine University Duisburg\u2010Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsolt","family":"Jur\u00e1nyi","sequence":"additional","affiliation":[{"name":"Department of Radiobiology and Diagnostic Onco\u2010Cytogenetics Centre of Radiotherapy National Institute of Oncology Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsa","family":"Kocsis","sequence":"additional","affiliation":[{"name":"Department of Radiobiology and Diagnostic Onco\u2010Cytogenetics Centre of Radiotherapy National Institute of Oncology Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahrokh F.","family":"Shariat","sequence":"additional","affiliation":[{"name":"Department of Urology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Sevcenco","sequence":"additional","affiliation":[{"name":"Department of Urology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Maj\u2010Hes","sequence":"additional","affiliation":[{"name":"Department of Urology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gero","family":"Kramer","sequence":"additional","affiliation":[{"name":"Department of Urology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2015.08.002"},{"key":"e_1_2_7_4_1","first-page":"148","article-title":"Neuroendocrine differentiation in prostate cancer","volume":"1","author":"Sun Y","year":"2009","journal-title":"Am J Transl Res"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2014.00060"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2015.02.010"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-2921-T"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-3309"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2013.69"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.10347"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-07-0089"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2012.07.012"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-016-0171-5"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-14-0071"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13493"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13781"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23397"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.22890"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-33774-4"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-018-0046-9"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.4487"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2015-0782"},{"key":"e_1_2_7_23_1","first-page":"5117","article-title":"Prospective evaluation of neuromediator dynamics in castration\u2010resistant prostate cancer patients during docetaxel","volume":"37","author":"Von Hardenberg J","year":"2017","journal-title":"Anticancer Res"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.03.017"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2003.11.032"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2014.05.008"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/01485010390129160"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1593\/neo.122070"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.3233\/CBM-2011-0198"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-17-0937"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004563213489670"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbju.15086","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.15086","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bju.15086","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.15086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:07:27Z","timestamp":1761743247000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.15086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,14]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/bju.15086"],"URL":"https:\/\/doi.org\/10.1111\/bju.15086","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,14]]},"assertion":[{"value":"2020-04-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}