{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:39:27Z","timestamp":1790199567346,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T00:00:00Z","timestamp":1591228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006156","name":"Sidney Kimmel Foundation for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate treatment patterns and associated outcomes of patients with urethral cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>After obtaining institutional review board approval we identified 165 patients treated for primary urethral cancer between 1956 and 2017. Treatment included monotherapy (surgery or radiation), dual therapy (surgery+radiation, surgery+chemotherapy, or chemotherapy+radiation) or triple therapy (surgery+radiation+chemotherapy). Rates of different treatments were described by treatment year. The association between treatment type and outcomes was evaluated with\u00a0multivariable Cox regression models, adjusting for disease characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study cohort included 74 men and 91 women, with a median age of 61\u00a0years. Common histologies were squamous cell (36%), urothelial (27%) and adenocarcinoma (25%). At presentation, 72% of patients had invasive disease, 24% had nodal involvement, and 5% had metastases. Treatment included monotherapy (57%), dual therapy (21%), and triple therapy (10%). The use of monotherapy decreased over time, while rates of dual therapy remained consistent, and rates of triple therapy increased. The median follow\u2010up was 4.7\u00a0years. Estimated 5\u2010year local recurrence\u2010free, disease\u2010specific and overall survival were 51%, 48% and 41%, respectively. Monotherapy was associated with decreased local recurrence\u2010free survival after adjusting for stage, histology, sex and year of treatment (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.017). There was no evidence that treatment type was associated with distant recurrence, cancer\u2010specific or overall survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found preliminary evidence that multimodal therapy, more commonly used in recent years, was of benefit in patients with primary urethral cancer. This finding should be confirmed in further studies involving multiple centres because of the low incidence of the disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15095","type":"journal-article","created":{"date-parts":[[2020,4,26]],"date-time":"2020-04-26T10:40:20Z","timestamp":1587897620000},"page":"359-366","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Primary urethral cancer: treatment patterns and associated outcomes"],"prefix":"10.1111","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3855-0211","authenticated-orcid":false,"given":"Roy","family":"Mano","sequence":"first","affiliation":[{"name":"Department of Surgery Urology Service Memorial Sloan Kettering Cancer Centre New York NY USA"},{"name":"Department of Urology Tel\u2010Aviv Sourasky Medical Centre Sackler School of Medicine Tel\u2010Aviv University Tel Aviv\u2010Yafo Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily A.","family":"Vertosick","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Centre New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Sarcona","sequence":"additional","affiliation":[{"name":"Department of Surgery Urology Service Memorial Sloan Kettering Cancer Centre New York NY USA"},{"name":"Department of Urology Lenox Hill Hospital New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel D.","family":"Sjoberg","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Centre New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole E.","family":"Benfante","sequence":"additional","affiliation":[{"name":"Department of Surgery Urology Service Memorial Sloan Kettering Cancer Centre New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy F.","family":"Donahue","sequence":"additional","affiliation":[{"name":"Department of Surgery Urology Service Memorial Sloan Kettering Cancer Centre New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry W.","family":"Herr","sequence":"additional","affiliation":[{"name":"Department of Surgery Urology Service Memorial Sloan Kettering Cancer Centre New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Machele","family":"Donat","sequence":"additional","affiliation":[{"name":"Department of Surgery Urology Service Memorial Sloan Kettering Cancer Centre New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard H.","family":"Bochner","sequence":"additional","affiliation":[{"name":"Department of Surgery Urology Service Memorial Sloan Kettering Cancer Centre New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Dalbagni","sequence":"additional","affiliation":[{"name":"Department of Surgery Urology Service Memorial Sloan Kettering Cancer Centre New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3092-9024","authenticated-orcid":false,"given":"Alvin C.","family":"Goh","sequence":"additional","affiliation":[{"name":"Department of Surgery Urology Service Memorial Sloan Kettering Cancer Centre New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.08.008"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.1998.00878.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(98)00659-1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1078-1439(03)00174-1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-015-1583-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2017.08.006"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2016.09.042"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.10.031"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/UA.UA_136_17"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S139252"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65669-8"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.09.068"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2014.07.105"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2012.01.011"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv230"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2017.07.026"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2018.06.007"},{"key":"e_1_2_7_19_1","unstructured":"Network National Comprehensive Cancer.Bladder Cancer (Version 1.2019). vol. 2019"},{"key":"e_1_2_7_20_1","volume-title":"European Association of Urology Guidelines","author":"Gakis G","year":"2018"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12630"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbju.15095","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.15095","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:24:48Z","timestamp":1761740688000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.15095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,4]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1111\/bju.15095"],"URL":"https:\/\/doi.org\/10.1111\/bju.15095","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,4]]},"assertion":[{"value":"2020-06-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}