{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T03:05:57Z","timestamp":1774580757120,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the utility of blue\u2010light flexible cystoscopy (BLFC) for surveillance of non\u2010muscle\u2010invasive bladder cancer (NMIBC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Prospective cohort of consecutive patients who underwent office\u2010based BLFC for NMIBC. Clinical information was collected including cystoscopic findings and pathological data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 322 cases were performed on 190 patients. The mean age was 71\u00a0years and 83% were men. The highest stage prior to BLFC was Ta, carcinoma\n                      <jats:italic>in situ<\/jats:italic>\n                      (CIS), T1, and T2 in 45.3%, 18.4%, 30% and 2%, respectively. Prior to BLFC, 16.8%, 60.5%, and 16.8% were low grade (LG), high grade (HG), and CIS, respectively. Intravesical bacille Calmette\u2013Gu\u00e9rin and intravesical chemotherapy were used in 54.2% and 18.4%, respectively. White\u2010light cystoscopy (WLC) and BLFC were both normal in 173 (53.7%) of cases. WLC was normal and BLFC was abnormal in 26 (8%) cases. Of these, 15 had office\u2010based biopsy and cancer was detected in 13 (87%; six CIS, four HG Ta, three LG Ta). Both WLC and BLFC were positive in 83 (25.8%) cases and 33% had additional tumours found. Cancer was found in 27 (75%) of WLC+\/BLFC+ who underwent office\u2010based biopsy including 19 LG Ta, six HG Ta, and two CIS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Incorporation of BLFC in clinical practice has potential advantages of finding cancer in cases with normal WLC. BLFC detected additional cancers in 33% of patients with positive WLC and BLFC, which can improve surveillance and performance of office\u2010based biopsy. Further research is needed to determine cost\u2010effectiveness and impact on recurrence rates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15166","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T10:14:55Z","timestamp":1594376095000},"page":"108-113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Prospective evaluation of blue\u2010light flexible cystoscopy with hexaminolevulinate in non\u2010muscle\u2010invasive bladder cancer"],"prefix":"10.1111","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5692-2723","authenticated-orcid":false,"given":"Yair","family":"Lotan","sequence":"first","affiliation":[{"name":"Department of Urology UT Southwestern Medical Center Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iftach","family":"Chaplin","sequence":"additional","affiliation":[{"name":"Department of Urology UT 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