{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T12:37:50Z","timestamp":1785847070238,"version":"3.56.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T00:00:00Z","timestamp":1597622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>(I) To determine Vesical Imaging\u2010Reporting and Data System (VI\u2010RADS) score 5 accuracy in predicting locally advanced bladder cancer (BCa), so as to potentially identify those patients who could avoid the morbidity of deep transurethral resection of bladder tumour (TURBT) in favour of histological sampling\u2010TUR prior to radical cystectomy (RC). (II) To explore the predictive value of VI\u2010RADS score 5 on time\u2010to\u2010cystectomy (TTC) outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed patients\u2019 ineligible or refusing cisplatin\u2010based combination neoadjuvant chemotherapy who underwent multiparametric magnetic resonance imaging (mpMRI) of the bladder prior to staging TURBT followed by RC for muscle\u2010invasive BCa. Sensitivity, specificity, positive and negative predictive values (PPV, NPV) were calculated for VI\u2010RADS score 5 vs. score 2\u20134 cases to assess the accuracy of mpMRI for extravesical BCa detection (\u2265pT3). VI\u2010RADS score performance was assessed by receiver operating characteristics curve analysis. A \u039a statistic was calculated to estimate mpMRI and pathological diagnostic agreement. The risk of delayed TTC (i.e. time from initial BCa diagnosis of &gt;3\u00a0months) was assessed using multivariable logistic regression model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 149 T2\u2013T4a, cN0\u2013M0 patients (VI\u2010RADS score 5,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a039 vs VI\u2010RADS score 2\u20134,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0110) were examined. VI\u2010RADS score 5 demonstrated sensitivity, specificity, PPV and NPV, in detecting extravesical disease of 90.2% (95% confidence interval [CI] 84\u201394.3), 98.1% (95% CI 94\u201399.6), 94.9% (95% CI 89.6\u201397.6) and 96.4% (95% CI 91.6\u201398.6), respectively. The area under the curve was 94.2% (95% CI 88.7\u201399.7) and inter\u2010reader agreement was excellent (\u039a\n                      <jats:sub>inter<\/jats:sub>\n                      0.89). The mean (SD) TTC was 4.2\u00a0(2.3) and 2.8\u00a0(1.1)\u00a0months for score 5 vs 2\u20134, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). VI\u2010RADS score 5 was found to independently increase risk of delayed TTC (odds ratio 2.81, 95% CI 1.20\u20136.62).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The VI\u2010RADS is valid and reliable in differentiating patients with extravesical disease from those with muscle\u2010confined BCa before TURBT. Detection of VI\u2010RADS score 5 was found to predict significant delay in TTC independently from other clinicopathological features. In the future, higher VI\u2010RADS scores could potentially avoid the morbidity of extensive primary resections in favour of sampling\u2010TUR for histology. Further prospective, larger, and multi\u2010institutional trials are required to validate clinical applicability of our findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15188","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T11:50:46Z","timestamp":1595505046000},"page":"610-619","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Preoperative detection of Vesical Imaging\u2010Reporting and Data System (VI\u2010RADS) score 5 reliably identifies extravesical extension of urothelial carcinoma of the urinary bladder and predicts significant delayed time to cystectomy: time to reconsider the need for primary deep transurethral resection of bladder tumour in cases of locally advanced disease?"],"prefix":"10.1111","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3865-5988","authenticated-orcid":false,"given":"Francesco","family":"Del Giudice","sequence":"first","affiliation":[{"name":"Department of Departments of Maternal\u2010Infant and Urological Sciences \u201cSapienza\u201d University of Rome, Policlinico Umberto, Hospital Rome Italy"},{"name":"Department of Urology Stanford University, School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costantino","family":"Leonardo","sequence":"additional","affiliation":[{"name":"Department of Departments of Maternal\u2010Infant and Urological Sciences \u201cSapienza\u201d University of Rome, Policlinico Umberto, Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Simone","sequence":"additional","affiliation":[{"name":"Department of Urology \u201cRegina Elena\u201d National Cancer Institute IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Pecoraro","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences, Oncology &amp; Pathology \u201cSapienza\u201d University of Rome, Policlinico Umberto, Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ettore","family":"De Berardinis","sequence":"additional","affiliation":[{"name":"Department of Departments of Maternal\u2010Infant and Urological Sciences \u201cSapienza\u201d University of Rome, Policlinico Umberto, Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Cipollari","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences, Oncology &amp; Pathology \u201cSapienza\u201d University of Rome, Policlinico Umberto, Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Flammia","sequence":"additional","affiliation":[{"name":"Department of Departments of Maternal\u2010Infant and Urological Sciences \u201cSapienza\u201d University of Rome, Policlinico Umberto, Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0396-3203","authenticated-orcid":false,"given":"Marco","family":"Bicchetti","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences, Oncology &amp; Pathology \u201cSapienza\u201d University of Rome, Policlinico Umberto, Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Maria","family":"Busetto","sequence":"additional","affiliation":[{"name":"Department of Departments of Maternal\u2010Infant and Urological Sciences \u201cSapienza\u201d University of Rome, Policlinico Umberto, Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin I.","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Urology Stanford University, School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Gallucci","sequence":"additional","affiliation":[{"name":"Department of Departments of Maternal\u2010Infant and Urological Sciences \u201cSapienza\u201d University of Rome, Policlinico Umberto, Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Catalano","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences, Oncology &amp; Pathology \u201cSapienza\u201d University of Rome, Policlinico Umberto, Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8466-918X","authenticated-orcid":false,"given":"Valeria","family":"Panebianco","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences, Oncology &amp; Pathology \u201cSapienza\u201d University of Rome, Policlinico Umberto, Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2008.07966.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2011.10904.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14557"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12630"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2012.11751.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.09.006"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2016.03.151"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2014.05.100"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2017171028"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.09.019"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-017-4758-3"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.27090"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.04.029"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-019-06117-8"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.09.029"},{"key":"e_1_2_7_17_1","unstructured":"BabjukM BurgerM Comp\u00e9ratEet al.Guidelines on Non\u2010Muscle invasive Bladder Cancer 2020. Available at:https:\/\/uroweb.org\/guideline\/non\u2010muscle\u2010invasive\u2010bladder\u2010cancer\/."},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.10.018"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23462"},{"key":"e_1_2_7_20_1","unstructured":"WitjesJA BruinsM CathomasRet al.EAU Guidelines on Muscle\u2010invasive and Metastatic Bladder Cancer 2020. Available at:https:\/\/uroweb.org\/guideline\/bladder\u2010cancer\u2010muscle\u2010invasive\u2010and\u2010metastatic\/."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0302-2838(02)00068-4"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2009.05.047"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2019.09.008"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000181797.19395.03"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000086828.26001.ca"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)00644-0"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365590410029141"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64047-5"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2017.0056"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24052"},{"key":"e_1_2_7_31_1","first-page":"9","article-title":"Timing of radical cystectomy in Central Europe \u2013 multicenter study on factors influencing the time from diagnosis to radical treatment of bladder cancer patients","volume":"68","author":"Poletajew S","year":"2015","journal-title":"Cent European J Urol"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2017.01.011"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2018-0784"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-017-2449-8"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2014.06.083"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2020.02.007"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.03.046"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.03.012"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2019182506"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-019-02190-1"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20190401"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbju.15188","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.15188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:42:49Z","timestamp":1761741769000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.15188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,17]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1111\/bju.15188"],"URL":"https:\/\/doi.org\/10.1111\/bju.15188","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,17]]},"assertion":[{"value":"2020-08-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}