{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T17:49:37Z","timestamp":1778348977017,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T00:00:00Z","timestamp":1601251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the impact of two cycles of neoadjuvant chemotherapy (NAC) in patients who underwent nephroureterectomy for high\u2010risk cN0M0 upper tract urothelial carcinoma (UTUC), and to evaluate the efficacy of NAC in patients with localised disease (\u2264cT2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>We retrospectively analysed patients with high\u2010risk cN0M0 UTUC who received NAC followed by surgery, compared with a matched cohort who underwent initial surgery at Fujita Health University during 2005\u20132019. Baseline and tumour characteristics, overall survival (OS), cancer\u2010specific survival (CSS), and recurrence\u2010free survival (RFS) were compared between the cohorts. Cox proportional hazards models were used to identify predictors of survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were 117 and 67 patients in the study group and the control group, respectively. Significantly higher pathological downstaging (pDS) and lower lymphovascular invasion (LVI) were observed in the study group than in the control group (48% vs 22%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.008 and 29% vs 46%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.045, respectively). The NAC group had significantly better 5\u2010year OS (79% vs 53%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.003), 5\u2010year CSS (84% vs 66%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.008), and 5\u2010year RFS (80% vs 61%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.001) than the control group. The OS benefit of NAC was observed even in patients with localised (\u2264cT2) disease (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.019). Patients with LVI showed significantly worse CSS both in pathologically locally advanced (\u2265pT3) and in localised (\u2264pT2) tumours (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.048 and\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.018, respectively). Multivariate analysis identified LVI, NAC, and pDS as independent predictors of OS. Male sex and post\u2010NAC LVI were identified as predictors of worse survival in patients who underwent NAC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Two cycles of NAC improved the survival of patients with high\u2010risk UTUC, even in patients with localised disease. Although two cycles of NAC appear to be effective in cN0M0 high\u2010risk UTUC including localised disease, additional larger sample size multicentre prospective studies comparing short\u2010course NAC regimens followed by surgery and surgery alone are required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15230","type":"journal-article","created":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T03:30:25Z","timestamp":1599708625000},"page":"332-339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Two cycles of neoadjuvant chemotherapy improves survival in patients with high\u2010risk upper tract urothelial carcinoma"],"prefix":"10.1111","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8455-7364","authenticated-orcid":false,"given":"Kenji","family":"Zennami","sequence":"first","affiliation":[{"name":"Department of Urology Fujita Health University School of Medicine Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Sumitomo","sequence":"additional","affiliation":[{"name":"Department of Urology Fujita Health University School of Medicine Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Takahara","sequence":"additional","affiliation":[{"name":"Department of Urology Fujita Health University School of Medicine Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuhisa","family":"Nukaya","sequence":"additional","affiliation":[{"name":"Department of Urology Fujita Health University School of Medicine Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Takenaka","sequence":"additional","affiliation":[{"name":"Department of Urology Fujita Health University School of Medicine Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Fukaya","sequence":"additional","affiliation":[{"name":"Department of Urology Fujita Health University School of Medicine Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Ichino","sequence":"additional","affiliation":[{"name":"Department of Urology Fujita Health University School of Medicine Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohiko","family":"Fukami","sequence":"additional","affiliation":[{"name":"Department of Urology Fujita Health University Okazaki Medical Center Okazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitomi","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Urology Fujita Health University School of Medicine Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoru","family":"Kusaka","sequence":"additional","affiliation":[{"name":"Department of Urology Fujita Health University Okazaki Medical Center Okazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoichi","family":"Shiroki","sequence":"additional","affiliation":[{"name":"Department of Urology Fujita Health University School of Medicine Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.07.036"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21551"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2018.01.015"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.06524.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2010.09675.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67019-X"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30415-3"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000644"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hys166"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2017.03.013"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21551"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2018.08.003"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.12.054"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000737"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-020-01650-9"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2019.01.019"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28655"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14719"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.13010"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.2361"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7386140"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2009.12.029"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2011.10075.x"},{"key":"e_1_2_7_26_1","first-page":"10. DOI: 10.339","article-title":"Down\u2010grading of ipsilateral hydronephrosis by neoadjuvant chemotherapy correlates with favorable oncological outcomes in patients undergoing radical nephroureterectomy for ureteral carcinoma","volume":"23","author":"Miyake M","year":"2019","journal-title":"Diagnostics (Basel)"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.02.018"},{"key":"e_1_2_7_28_1","first-page":"157. DOI: 10.33","article-title":"Gender is a significant prognostic factor for upper tract urothelial carcinoma: a large hospital\u2010based cancer registry study in an endemic area","volume":"9","author":"Huang CC","year":"2019","journal-title":"Front Oncol"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12014"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbju.15230","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.15230","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bju.15230","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.15230","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T14:37:29Z","timestamp":1761748649000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.15230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,28]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/bju.15230"],"URL":"https:\/\/doi.org\/10.1111\/bju.15230","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,28]]},"assertion":[{"value":"2020-09-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}