{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T23:46:39Z","timestamp":1773099999737,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the differential response to neoadjuvant chemotherapy (NAC) in patients with urothelial carcinoma of the bladder (UCB) compared to upper tract urothelial carcioma (UTUC) treated with radical surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Data from 1299 patients with UCB and 276 with UTUC were obtained from multicentric collaborations. The association of disease location (UCB vs UTUC) with pathological complete response (pCR, defined as a post\u2010treatment pathological stage ypT0N0) and pathological objective response (pOR, defined as ypT0\u2010Ta\u2010Tis\u2010T1N0) after NAC was evaluated using logistic regression analyses. The association with overall (OS) and cancer\u2010specific survival (CSS) was evaluated using Cox regression analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A pCR was found in 250 (19.2%) patients with UCB and in 23 (8.3%) with UTUC (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      &lt;\u00a00.01). A pOR was found in 523 (40.3%) patients with UCB and in 133 (48.2%) with UTUC (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.02). On multivariable logistic regression analysis, patients with UTUC were less likely to have a pCR (odds ratio [OR] 0.45, 95% confidence interval [CI] 0.27\u20130.70;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.01) and more likely to have a pOR (OR 1.57, 95% CI 1.89\u20132.08;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.01). On univariable Cox regression analyses, UTUC was associated with better OS (hazard ratio [HR] 0.80, 95% CI 0.64\u20130.99,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.04) and CSS (HR 0.63, 95% CI 0.49\u20130.83;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.01). On multivariable Cox regression analyses, UTUC remained associated with CSS (HR 0.61, 95% CI 0.45\u20130.82;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.01), but not with OS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our present findings suggest that the benefit of NAC in UTUC is similar to that found in UCB. These data can be used as a benchmark to contextualise survival outcomes and plan future trial design with NAC in urothelial cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.15253","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T12:02:03Z","timestamp":1607083323000},"page":"528-537","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Comparative effectiveness of neoadjuvant chemotherapy in bladder and upper urinary tract urothelial carcinoma"],"prefix":"10.1111","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1625-1077","authenticated-orcid":false,"given":"David","family":"D\u2019Andrea","sequence":"first","affiliation":[{"name":"Department of Urology Comprehensive Cancer Center Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1638-1445","authenticated-orcid":false,"given":"Surena","family":"Matin","sequence":"additional","affiliation":[{"name":"Department of Urology MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter C.","family":"Black","sequence":"additional","affiliation":[{"name":"Department of Urologic Sciences University of British Columbia Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3062-0780","authenticated-orcid":false,"given":"Firas G.","family":"Petros","sequence":"additional","affiliation":[{"name":"Department of Urology and Kidney Transplant Eleanor N. Dana Cancer Center The University of Toledo Medical Center Toledo OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Homayoun","family":"Zargar","sequence":"additional","affiliation":[{"name":"Department of Urologic Sciences University of British Columbia Vancouver BC Canada"},{"name":"Department of Urology Western Health Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin P.","family":"Dinney","sequence":"additional","affiliation":[{"name":"Department of Urology MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Cookson","sequence":"additional","affiliation":[{"name":"Department of Urology Center and The Stephenson Cancer Center The University of Oklahoma Health Sciences Oklahoma City OK USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wassim","family":"Kassouf","sequence":"additional","affiliation":[{"name":"Division of Urology Department of Surgery McGill University Health Center Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2301-2683","authenticated-orcid":false,"given":"Marc A.","family":"Dall'Era","sequence":"additional","affiliation":[{"name":"Department of Urology Davis Medical Center University of California at Davis Sacramento CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9416-9912","authenticated-orcid":false,"given":"John S.","family":"McGrath","sequence":"additional","affiliation":[{"name":"Department of Urology University of Michigan Health System Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan L.","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Urology University of Washington Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew C.","family":"Thorpe","sequence":"additional","affiliation":[{"name":"Department of Urology Freeman Hospital Newcastle Upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd M.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Urology University of Michigan Health System Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey M.","family":"Holzbeierlein","sequence":"additional","affiliation":[{"name":"Department of Urology University of Kansas Medical Center Kansas City KS USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trinity J.","family":"Bivalacqua","sequence":"additional","affiliation":[{"name":"Department of Urology The Johns Hopkins School of Medicine The James Buchanan Brady Urological Institute Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srikala S.","family":"Sridhar","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology Princess Margaret Cancer Center Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"North","sequence":"additional","affiliation":[{"name":"Department of Oncology Cross Cancer Institute University of Alberta Edmonton AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel A.","family":"Barocas","sequence":"additional","affiliation":[{"name":"Department of Urologic Surgery Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5692-2723","authenticated-orcid":false,"given":"Yair","family":"Lotan","sequence":"additional","affiliation":[{"name":"Department of Urology University of Texas Southwestern Medical Center Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Stephenson","sequence":"additional","affiliation":[{"name":"Glickman Urological and Kidney Institute Cleveland Clinic Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bas W.","family":"van Rhijn","sequence":"additional","affiliation":[{"name":"Department of Urology The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital Amsterdam The 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